Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer

	Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer
	Huang, Yuan 1; Wang, Xiaowei 2; Zheng, Yiran 3; Chen, Wei 4; Zheng, Yabing 1; Li, Guangliang 1; Lou, Weiyang 5; Wang, Xiaojia 1
刊名	AGING-US
	2021-01-15
卷号	13
关键词	triple-negative breast cancer biomarker competing endogenous RNA prognosis
ISSN号	1945-4589
通讯作者	Huang, Yuan(huangyuan@zjcc.org.cn) ; Lou, Weiyang(11718264@zju.edu.cn) ; Wang, Xiaojia(wangxj@zjcc.org.cn)
英文摘要	The aim of this study was to establish a novel competing endogenous RNA (ceRNA) network able to predict prognosis in patients with triple-negative breast cancer (TNBC). Differential gene expression analysis was performed using the GEO2R tool. Enrichr and STRING were used to conduct protein-protein interaction and pathway enrichment analyses, respectively. Upstream lncRNAs and miRNAs were identified using miRNet and mirTarBase, respectively. Prognostic values, expression, and correlational relationships of mRNAs, lncRNAs, and miRNAs were examined using GEPIA, starBase, and Kaplan-Meier plotter. It total, 860 upregulated and 622 downregulated differentially expressed mRNAs were identified in TNBC. Ten overexpressed and two underexpressed hub genes were screened. Next, 10 key miRNAs upstream of these key hub genes were predicted, of which six upregulated miRNAs were significantly associated with poor prognosis and four downregulated miRNAs were associated with good prognosis in TNBC. NEAT1 and MAL2 were selected as key lncRNAs. An mRNA-miRNA-lncRNA network in TNBC was constructed. Thus, we successfully established a novel mRNA-miRNA-lncRNA regulatory network, each component of which is prognostic for TNBC.
资助项目	National Natural Science Foundation of China[NSFC-81502618] ; Zhejiang Provincial Natural Science Foundation of China[LQ16H160012] ; Zhejiang Provincial Research Center for Cancer Intelligent Diagnosis and Molecular Technology[JBZX-202003]
WOS关键词	LONG NONCODING RNA ; CERNA ; IDENTIFICATION ; METASTASIS ; BIOMARKER ; GROWTH ; CELLS
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000611141300009
资助机构	National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Zhejiang Provincial Research Center for Cancer Intelligent Diagnosis and Molecular Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/119629]
专题	中国科学院合肥物质科学研究院
通讯作者	Huang, Yuan; Lou, Weiyang; Wang, Xiaojia
作者单位	1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Breast Med Oncol,Canc Hosp,Univ Chinese Acad, Hangzhou 310022, Zhejiang, Peoples R China 2.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Colorectal Surg, Hangzhou 310016, Zhejiang, Peoples R China 3.Soochow Univ, Sch Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 4.Silergy Corp, Hangzhou 310012, Zhejiang, Peoples R China 5.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Breast Surg, Hangzhou 310003, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Huang, Yuan,Wang, Xiaowei,Zheng, Yiran,et al. Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer[J]. AGING-US,2021,13.
APA	Huang, Yuan.,Wang, Xiaowei.,Zheng, Yiran.,Chen, Wei.,Zheng, Yabing.,...&Wang, Xiaojia.(2021).Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer.AGING-US,13.
MLA	Huang, Yuan,et al."Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer".AGING-US 13(2021).