Development of biodegradable Zn-1Mg-0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications

doi:10.1016/j.actbio.2020.09.036

	Development of biodegradable Zn-1Mg-0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications
	Tong, Xian 3,5; Zhang, Dechuang 3; Lin, Jixing 5; Dai, Yilong 3; Luan, Yanan 4; Sun, Quanxiang 3; Shi, Zimu 6; Wang, Kun 5; Gao, Yao 5; Lin, Jianguo 3
刊名	ACTA BIOMATERIALIA
	2020-11-01
卷号	117
关键词	Anticoagulation Degradation behavior Mechanical properties Zn-based biodegradable metals Zn-Mg-RE alloys
ISSN号	1742-7061
DOI	10.1016/j.actbio.2020.09.036
通讯作者	Zhang, Dechuang(dczhang@xtu.edu.cn) ; Lin, Jixing(linjixing@163.com) ; Wen, Cuie(cuie.wen@rmit.edu.au)
英文摘要	Zinc (Zn) and its alloys are receiving great attention as promising biodegradable materials due to their suitable corrosion resistance, good biocompatibility, and highly desirable biofunctionality. Nevertheless, the low mechanical strength of pure Zn impedes its practical clinical application and there have been calls for further research into the Zn alloys and thermomechanical processes to enhance their mechanical properties and biocompatibility. Here, we report on the alloying efficacy of rare earth elements (REEs) including erbium (Er), dysprosium (Dy), and holmium (Ho) on the microstructure, mechanical properties, corrosion and wear behavior, and in vitro biological properties of Zn-1Mg-0.1RE alloys. Microstructural characterization revealed that the addition of 0.1 wt.% REEs had a significant refining effect on the grain size of the alpha-Zn matrix and the second phases of the alloys. Alloying of the REEs and hot-rolling effectively improved the mechanical properties due to both precipitation strengthening of the second phases of ErZn5, DyZn5, and Ho2Zn17 and grain-refinement strengthening. The highest ultimate tensile strength of 259.4 MPa and yield strength of 234.8 MPa with elongation of 16.8% were achieved in the hot-rolled Zn-1Mg-0.1Ho. Alloying of REEs also improved the wear and corrosion resistance, and slowed down the degradation rate in Hanks' solution. Zn-1Mg-0.1Er showed the highest cytocompatibility of MC3T3-E1 cells cultured directly on the alloy surface and of MG-63 cells cultured in the alloy extract. Zn-1Mg-0.1Dy showed the best anticoagulant property among all the alloys. Overall, these Zn-1Mg-0.1RE (Er, Dy, and Ho) alloys can be considered promising biodegradable metallic materials for orthopedic applications. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助项目	Wenzhou Science and Technology Bureau[ZG2019022] ; Wenzhou Science and Technology Bureau[2018ZG008] ; Australian Research Council (ARC)[DP170102557] ; Australian Research Council (ARC)[FT160100252] ; ARC Research Hub for Advanced Manufacturing of Medical Devices[IH150100024] ; National Natural Science Foundation of China[11872053] ; National Natural Science Foundation of China[51971190] ; Scientific Research Fund of Hunan Provincial Science and Technology Department[2018JJ4053] ; Scientific Research Fund of Hunan Provincial Science and Technology Department[18A065]
WOS关键词	IN-VITRO DEGRADATION ; RARE-EARTH-ELEMENTS ; MECHANICAL-PROPERTIES ; CORROSION PROPERTIES ; MAGNESIUM ALLOYS ; BINARY-ALLOYS ; ZN ; MG ; BEHAVIOR ; BONE
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000585309100031
资助机构	Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) ; ARC Research Hub for Advanced Manufacturing of Medical Devices ; National Natural Science Foundation of China ; Scientific Research Fund of Hunan Provincial Science and Technology Department
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/105095]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Dechuang; Lin, Jixing; Wen, Cuie
作者单位	1.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia 2.Univ Queensland, Ctr Adv Mat Proc & Mfg AMPAM, Brisbane, Qld 4072, Australia 3.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 4.Beijing Univ Technol, Coll Environm & Energy Engn, Beijing 100000, Peoples R China 5.Zhejiang Ind & Trade Vocat Coll, Dept Mat Engn, Wenzhou 325003, Peoples R China 6.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Tong, Xian,Zhang, Dechuang,Lin, Jixing,et al. Development of biodegradable Zn-1Mg-0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications[J]. ACTA BIOMATERIALIA,2020,117.
APA	Tong, Xian.,Zhang, Dechuang.,Lin, Jixing.,Dai, Yilong.,Luan, Yanan.,...&Wen, Cuie.(2020).Development of biodegradable Zn-1Mg-0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications.ACTA BIOMATERIALIA,117.
MLA	Tong, Xian,et al."Development of biodegradable Zn-1Mg-0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications".ACTA BIOMATERIALIA 117(2020).