Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer

doi:10.1097/CM9.0000000000000910

	Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer
	Wang, Xing 1,2; Wang, Xiao-Lei 3
刊名	CHINESE MEDICAL JOURNAL
	2020-10-05
卷号	133
关键词	Children and adolescents Differentiated thyroid cancer Recurrence
ISSN号	0366-6999
DOI	10.1097/CM9.0000000000000910
通讯作者	Wang, Xiao-Lei(wangxlcams@126.com)
英文摘要	Background: The standard treatment for pediatric differentiated thyroid carcinoma (DTC) still requires consideration because of a lack of clinical evidence. The purpose of this study was to summarize the clinical experiences and explore the risk factors for post-operative recurrence through a retrospective analysis to develop better clinical strategies for pediatric DTC. Methods: This study retrospectively analyzed children and adolescents with DTC who were treated between January 1999 and December 2014 at the Cancer Hospital, Chinese Academy of Medical Sciences. Clinicopathological results and outcomes were collected. A log-rank test of Kaplan-Meier curves and the Cox regression model were used to determine the factors associated with recurrence. Results: Data of 150 patients were collected in this study. During the follow-up, there was only one disease-related death. The recurrence rates at 3, 5, and 10 years were 13.6%, 18.7%, and 28.6%, respectively. There was a significant difference in the rate of recurrence according to age (P < 0.001), extrathyroidal extension (P < 0.001), lymph node metastasis (P = 0.023), and invasion of the trachea and esophageal wall (P = 0.004). Cox regression analysis demonstrated that age (P = 0.006) and extrathyroidal extension (P = 0.013) were significant dependent factors of post-operative recurrence. Conclusions: The prognosis of DTC in children and adolescents is favorable. A close follow-up is recommended because of the high recurrence rate. A comparatively higher recurrence rate was observed in the younger age group, and new age-based divisions may be needed to conveniently evaluate the possibility of recurrence.
WOS关键词	PREDICTIVE FACTORS ; CARCINOMA ; COMPLICATIONS ; DISEASE
WOS研究方向	General & Internal Medicine
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000577959000004
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104563]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Xiao-Lei
作者单位	1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou 310022, Zhejiang, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Head Neck Surg,Natl Canc Ctr, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xing,Wang, Xiao-Lei. Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer[J]. CHINESE MEDICAL JOURNAL,2020,133.
APA	Wang, Xing,&Wang, Xiao-Lei.(2020).Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer.CHINESE MEDICAL JOURNAL,133.
MLA	Wang, Xing,et al."Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer".CHINESE MEDICAL JOURNAL 133(2020).