2019-nCoV may create complications in colon cancer patients with ACE2 expression

	2019-nCoV may create complications in colon cancer patients with ACE2 expression
	Chen, Yongyi 1,2,3; Gong, Wangang 1,2,3; Wei, Haibin 1,2,3; Dai, Wumin 1,2,3; Xu, Songxiao 1,2,3
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
	2020
卷号	13
关键词	2019-nCoV colon cancer ACE2 bioinformatics
ISSN号	1936-2625
通讯作者	Xu, Songxiao(xusx@zjcc.org.cn)
英文摘要	Since December 2019, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans. Much remains unknown about 2019-nCoV, especially the additional risks that 2019-nCoV infection may pose for colon cancer patients. Many reports show that angiotensin converting enzyme II (ACE2) is the cell receptor through which 2019-nCoV enters host cells, and this is similar to the cell entry mechanism of SARS coronavirus. Previous studies show that ACE2 is highly expressed in the gastrointestinal tract, especially in the colon. In patients with colon cancer, ACE2 expression is significantly increased in tumor tissues compared to tissues from patients with other types of cancer. One of the known regulators of endocytosis is the serine protease (TMPRSS2) and AP2-associated protein kinase 1 (AAK1), which also facilitates the passage of viruses into cells. Furthermore, the Database of Gene expression profiling interactive analysis suggests that expression levels for ACE2, TMPRSS2, and AAK1 are positively correlated in colon cells. Therefore, our findings predict that 2019-nCoV will create increased complications for patients with colon cancer.
WOS研究方向	Oncology ; Pathology
语种	英语
出版者	E-CENTURY PUBLISHING CORP
WOS记录号	WOS:000576775000010
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104449]
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Songxiao
作者单位	1.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Clin Lab, 1 East Banshan Rd, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yongyi,Gong, Wangang,Wei, Haibin,et al. 2019-nCoV may create complications in colon cancer patients with ACE2 expression[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2020,13.
APA	Chen, Yongyi,Gong, Wangang,Wei, Haibin,Dai, Wumin,&Xu, Songxiao.(2020).2019-nCoV may create complications in colon cancer patients with ACE2 expression.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,13.
MLA	Chen, Yongyi,et al."2019-nCoV may create complications in colon cancer patients with ACE2 expression".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 13(2020).