An improved beam splitting method for intensity modulated proton therapy

doi:10.1088/1361-6560/ab9b55

	An improved beam splitting method for intensity modulated proton therapy
	Yang, Jinhe 1,2; He, Peng 2; Wang, Hui 2; Sun, Guangyao 2; Zheng, Huaqing 2; Jia, Jing 2
刊名	PHYSICS IN MEDICINE AND BIOLOGY
	2020-09-21
卷号	65
关键词	beam splitting KylinRay IMPT pencil beam algorithm TOPAS proton therapy
ISSN号	0031-9155
DOI	10.1088/1361-6560/ab9b55
通讯作者	Wang, Hui(theonlyhuiwang@gmail.com)
英文摘要	The pencil beam algorithm (PBA) has become the predominant dose calculation method in proton therapy, due to its high level of efficiency. However, density heterogeneity decreases the accuracy of PBA. To improve PBA's accuracy, a beam splitting method is used to divide the original scanning beam into multiple thinner beamlets. Beam splitting should ensure that the beamlets' summed fluence is as close to the original beam fluence as possible, while keeping the spatial variance of beamlets small, and minimizing the number of beamlets. In this work, the generalized differential evolution (GDE) algorithm is utilized for the optimal scheme. Under reasonable constraints for the radius and weight of beamlets, several schemes are optimized via the GDE algorithm. In order to achieve a trade-off between accuracy and calculation speed, three hexagon-based schemes, which split the original beam into 7, 13, and 19 beamlets, respectively, are proposed and compared with the scheme of Raystation 4.5. The fluence distribution calculated by the schemes with 13 beamlets and 19 beamlets are demonstrated to be more accurate than the Raystation scheme, which has 19 beamlets, with a maximum absolute difference between the summed beamlets fluence and the original beam fluence of 2.12%, and 0.93%, respectively. Furthermore, beam splitting schemes are implemented into a proton dose calculation algorithm based on the KylinRay-IMPT TPS. These schemes, based on the dose algorithm, are compared with the Monte Carlo program TOPAS 3.2 in slab geometry with lateral heterogeneity. The dose, calculated by the dose algorithm using a scheme of 13 beamlets, shows a good agreement with the dose from TOPAS. In addition, an abdominal geometry is used for further verification. Gamma analysis passing rates greater than 99.7% are observed, with a 2%/2 mm criterion. Thus, the accuracy and effectiveness of the improved beam splitting method are preliminarily verified.
资助项目	National Natural Science Foundation of China[11 605 233] ; Anhui province project[18 030 801 135] ; Chinese Academy of Sciences project[XXH13506-104] ; Special Project of Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Industrialization Fund
WOS关键词	CARLO DOSE CALCULATION ; ALGORITHM ; RADIOTHERAPY ; SYSTEM
WOS研究方向	Engineering ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000573533000001
资助机构	National Natural Science Foundation of China ; Anhui province project ; Chinese Academy of Sciences project ; Special Project of Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Industrialization Fund
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104359]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Hui
作者单位	1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab Neutron & Radiat Safety, Inst Nucl Energy Safety Technol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jinhe,He, Peng,Wang, Hui,et al. An improved beam splitting method for intensity modulated proton therapy[J]. PHYSICS IN MEDICINE AND BIOLOGY,2020,65.
APA	Yang, Jinhe,He, Peng,Wang, Hui,Sun, Guangyao,Zheng, Huaqing,&Jia, Jing.(2020).An improved beam splitting method for intensity modulated proton therapy.PHYSICS IN MEDICINE AND BIOLOGY,65.
MLA	Yang, Jinhe,et al."An improved beam splitting method for intensity modulated proton therapy".PHYSICS IN MEDICINE AND BIOLOGY 65(2020).