Molecular subtyping of glioblastoma based on immune-related genes for prognosis

doi:10.1038/s41598-020-72488-4

	Molecular subtyping of glioblastoma based on immune-related genes for prognosis
	Chen, Xueran 1,5; Fan, Xiaoqing 2,3; Zhao, Chenggang 4,5; Zhao, Zhiyang 4,5; Hu, Lizhu 4,5; Wang, Delong 2,3; Wang, Ruiting 2,3; Fang, Zhiyou 1,5
刊名	SCIENTIFIC REPORTS
	2020-09-23
卷号	10
ISSN号	2045-2322
DOI	10.1038/s41598-020-72488-4
通讯作者	Chen, Xueran(xueranchen@cmpt.ac.cn)
英文摘要	Glioblastoma (GBM) is associated with an increasing mortality and morbidity and is considered as an aggressive brain tumor. Recently, extensive studies have been carried out to examine the molecular biology of GBM, and the progression of GBM has been suggested to be correlated with the tumor immunophenotype in a variety of studies. Samples in the current study were extracted from the ImmPort and TCGA databases to identify immune-related genes affecting GBM prognosis. A total of 92 immune-related genes displaying a significant correlation with prognosis were mined, and a shrinkage estimate was conducted on them. Among them, the 14 most representative genes showed a marked correlation with patient prognosis, and LASSO and stepwise regression analysis was carried out to further identify the genes for the construction of a predictive GBM prognosis model. Then, samples in training and test cohorts were incorporated into the model and divided to evaluate the efficiency, stability, and accuracy of the model to predict and classify the prognosis of patients and to identify the relevant immune features according to the median value of RiskScore (namely, Risk-H and Risk-L). In addition, the constructed model was able to instruct clinicians in diagnosis and prognosis prediction for various immunophenotypes.
资助项目	National Natural Science Foundation of China[81872066] ; National Natural Science Foundation of China[31571433] ; National Natural Science Foundation of China[81773131] ; National Natural Science Foundation of China[81972635] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2018CXFX004] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2017FXCX008] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2018487]
WOS关键词	MESSENGER-RNA EXPRESSION ; STEM-CELLS ; CANCER ; SIGNATURE ; SUPPRESSOR ; MULTIFORME ; EGFR
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000573849300023
资助机构	National Natural Science Foundation of China ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Youth Innovation Promotion Association of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104332]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Xueran
作者单位	1.Chinese Acad Sci, Hefei Canc Hosp, Dept Mol Pathol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China USTC, Affiliated Hosp USTC 1, Div Life Sci & Med, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China 3.Anhui Prov Hosp, Dept Anesthesiol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China 4.Univ Sci & Technol China, 96 Jin Zhai Rd, Hefei 230026, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xueran,Fan, Xiaoqing,Zhao, Chenggang,et al. Molecular subtyping of glioblastoma based on immune-related genes for prognosis[J]. SCIENTIFIC REPORTS,2020,10.
APA	Chen, Xueran.,Fan, Xiaoqing.,Zhao, Chenggang.,Zhao, Zhiyang.,Hu, Lizhu.,...&Fang, Zhiyou.(2020).Molecular subtyping of glioblastoma based on immune-related genes for prognosis.SCIENTIFIC REPORTS,10.
MLA	Chen, Xueran,et al."Molecular subtyping of glioblastoma based on immune-related genes for prognosis".SCIENTIFIC REPORTS 10(2020).