Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease

	Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease
	Xu, Xiaowen 1,2,4; Meng, Tong 2; Wen, Qingqing 3; Tao, Mengling 1,2; Wang, Peijun 1,2; Zhong, Kai 5,6,7; Shen, Yong 4
刊名	AGING-US
	2020-09-15
卷号	12
关键词	Alzheimer's disease hippocampus magnetic resonance imaging vessel size imaging early diagnosis
ISSN号	1945-4589
通讯作者	Wang, Peijun(tongjipjwang@vip.sina.com) ; Zhong, Kai(kzhong@hmfl.ac.cn) ; Shen, Yong(yongshen@ustc.edu.cn)
英文摘要	Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Here, we used vessel size imaging to investigate the specific microvascular changes and most susceptible brain regions during AD progression in an amyloid precursor protein 23 (APP23) transgenic AD mouse model. Using 9.4 Tesla magnetic resonance imaging (MRI), the values of microvascular density (Density), mean vessel diameter (mVD), and vessel size index (VSI) were compared between APP23 and wild-type (WT) mice at 3, 6, 9, 14, and 20 months of age. Our results demonstrate that in 20-month old APP23 and WT mice, the Density values were significantly decreased, while the vascular dilatation and diameter had increased. However, a transient increase in the cortex Density at 14-months was observed in APP23 mice. Additionally, our results suggest that the hippocampus is the susceptible brain region affected by the abnormal microvascular angiogenesis during the early stages of AD. Together, our findings indicate that vessel size imaging using MRI can provide novel biomarkers for the early detection of AD, and for monitoring the effects of vascular-targeted therapeutics in AD.
资助项目	National Key R&D Program of China[2016YFC1305500] ; National Key R&D Program of China[2016YFC1300500-3] ; National Natural Science Foundation of China[61471399] ; National Natural Science Foundation of China[61671479] ; National Natural Science Foundation of China[U1604284] ; National Natural Science Foundation of China[81670663] ; National Natural Science Foundation of China[81830059] ; National Natural Science Foundation of China[81571655] ; National Natural Science Foundation of China[81771889] ; National Natural Science Foundation of China[91649101] ; Shanghai Municipal Commission of Health and Family Planning Smart Medical Special Research Project[2018ZHYL0105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01030200]
WOS关键词	APP23 ; AGE ; MICROVASCULATURE ; DEPOSITION ; MORPHOLOGY ; PATHOLOGY ; DEMENTIA ; MODEL ; MRI
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000572847000015
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; Shanghai Municipal Commission of Health and Family Planning Smart Medical Special Research Project ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104311]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Peijun; Zhong, Kai; Shen, Yong
作者单位	1.Tongji Univ, Tongji Hosp, Sch Med, Dept Radiol, Shanghai, Peoples R China 2.Tongji Univ, Sch Med, Shanghai, Peoples R China 3.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Key Lab Biomed Engn,Minist Educ, Hangzhou, Zhejiang, Peoples R China 4.Univ Sci & Technol China, Div Life & Med Sci,CAS Key Lab Brain Funct & Brai, Neurodegenerat Disorder Res Ctr,Hefei Mat Sci Nat, Inst Aging & Brain Disorders,Univ Affiliated Hosp, Hefei, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China 6.Key Lab Anhui Prov High Field Magnet Resonance Im, Hefei, Peoples R China 7.Chinese Acad Sci, High Magnet Field Lab, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaowen,Meng, Tong,Wen, Qingqing,et al. Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease[J]. AGING-US,2020,12.
APA	Xu, Xiaowen.,Meng, Tong.,Wen, Qingqing.,Tao, Mengling.,Wang, Peijun.,...&Shen, Yong.(2020).Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease.AGING-US,12.
MLA	Xu, Xiaowen,et al."Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease".AGING-US 12(2020).