Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer

doi:10.21037/tcr.2020.01.67

	Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer
	Luo, Taobo 1,2,3; Chen, Qixun 1,2,3; Zeng, Jian 1,2,3
刊名	TRANSLATIONAL CANCER RESEARCH
	2020-03-01
卷号	9
关键词	Clinical pathology lymph node metastasis non-small cell lung cancer (NSCLC)
ISSN号	2218-676X
DOI	10.21037/tcr.2020.01.67
通讯作者	Zeng, Jian(68640770@qq.com)
英文摘要	Background: Lymph node metastasis occurs although clinical stage IA is a relatively early stage for patients with non-small cell lung cancer (NSCLC). This study aimed to explore the influencing factors of lymph node metastasis. Methods: A total of 200 patients diagnosed with clinical stage IA NSCLC preoperatively from July 2014 to July 2016 were examined. Every patient underwent lobectomy and systematic lymph node dissection. Their clinicopathological characteristics and status of lymph node metastasis are analyzed. Results: The rates of both N1 and N2 lymph node metastasis increase with the increase in the tumor diameter. The N1 lymph node metastasis rate is 0%, 2.82%, and 9.52%, while the N2 lymph node metastasis rate is 0%, 4.23%, and 25.40% for pure ground-glass nodules, mixed ground-glass nodules (solid component <50%), and mixed ground-glass nodules (solid component >50%), respectively. The difference is statistically significant (P=0.000). Patients with squamous cell carcinoma have a relatively higher N1 lymph node metastasis rate comparing with patients with adenocarcinoma (P<0.05). Tumors locate in the inner half lobe (close to hilus) are prone to metastasize to lymph nodes (P=0.018). Multiple regression analysis shows that tumor diameter, solid component rate, and tumor location are relevant factors for lymph node metastasis. Conclusions: In patients with NSCLC, who have tumors smaller than 1 cm, pure ground-glass nodules, or tumors locate in the lateral half lobe, lymph node metastasis is rare and selective lymphadenectomy is considerable.
WOS关键词	SELECTIVE MEDIASTINAL LYMPHADENECTOMY ; QUALITY-OF-LIFE ; SURGICAL-TREATMENT ; DISSECTION ; SURVIVAL ; RECURRENCE ; NODULES
WOS研究方向	Oncology
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000522761900029
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103527]
专题	中国科学院合肥物质科学研究院
通讯作者	Zeng, Jian
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Peoples R China 2.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Thorac Surg, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Luo, Taobo,Chen, Qixun,Zeng, Jian. Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer[J]. TRANSLATIONAL CANCER RESEARCH,2020,9.
APA	Luo, Taobo,Chen, Qixun,&Zeng, Jian.(2020).Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer.TRANSLATIONAL CANCER RESEARCH,9.
MLA	Luo, Taobo,et al."Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer".TRANSLATIONAL CANCER RESEARCH 9(2020).