Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry

doi:10.1007/s00216-020-02602-y

	Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry
	Zhou, Wenzhao 1,2; Huang, Chaoqun 1; Zou, Xue 1; Lu, Yan 1; Xia, Lei 1; Shen, Chengyin 1; Chu, Yannan 1
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2020-06-01
卷号	412
关键词	Breath analysis Modified APPI QTOFMS
ISSN号	1618-2642
DOI	10.1007/s00216-020-02602-y
通讯作者	Huang, Chaoqun(cqhuang@aiofm.ac.cn)
英文摘要	Breath analysis is a promising method for metabolomics studies and clinical diagnosis, as it enables the observation of metabolites in a convenient and noninvasive way. In this work, an atmospheric pressure photoionization (APPI) source was modified for online analysis of exhaled breath by coupling with quadrupole time-of-flight mass spectrometry (QTOFMS). Three parameters, namely, the capillary voltage, the sampling flow and the curtain gas flow of the APPI source, were optimized. Five healthy volunteers, three males and two females, were enrolled to test the performance of modified APPI-QTOFMS by analyzing their exhaled breath. A total of 21 compounds were tentatively identified, and four metabolites, namely, dimethyl selenoxide, delta-valerolactam, hydroxymandelic acid and palmitic amide were detected in the exhaled breath for the first time. The result shows that modified APPI-QTOFMS can be used for the online study of exhaled breath.
资助项目	National Natural Science Foundation of China[61671434] ; National Natural Science Foundation of China[21876176] ; Key Program of 13th Five-Year Plan CASHIPS[KP-2017-25]
WOS关键词	VOLATILE ORGANIC-COMPOUNDS ; ELECTROSPRAY-IONIZATION ; HUMAN SALIVA ; PTR-MS ; AIR ; ACETONE ; OXIDATION ; MICROEXTRACTION ; QUANTIFICATION ; CONDENSATE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000528432100001
资助机构	National Natural Science Foundation of China ; Key Program of 13th Five-Year Plan CASHIPS
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103373]
专题	中国科学院合肥物质科学研究院
通讯作者	Huang, Chaoqun
作者单位	1.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China 2.Zhejiang Inst Metrol, 300 Xiasha Rd, Hangzhou 310018, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Wenzhao,Huang, Chaoqun,Zou, Xue,et al. Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2020,412.
APA	Zhou, Wenzhao.,Huang, Chaoqun.,Zou, Xue.,Lu, Yan.,Xia, Lei.,...&Chu, Yannan.(2020).Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,412.
MLA	Zhou, Wenzhao,et al."Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 412(2020).