The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer

doi:10.21037/tlcr-20-609

	The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer
	Li, Qian 2; Liu, Yu 2; Su, Bin 2; Zhao, Hongguang 2; Lin, Qingren 1; Zhu, Yaoyao 2; Zhang, Lingnan 3; Weng, Denghu 1; Gong, Xiaomei 2; Sun, Xiaojiang 1
刊名	TRANSLATIONAL LUNG CANCER RESEARCH
	2020-06-01
卷号	9
关键词	Radiation-induced lung injury (RILI) tumor recurrence stereotactic body radiation therapy (SBRT) early stage non-small cell lung cancer
ISSN号	2218-6751
DOI	10.21037/tlcr-20-609
通讯作者	Gong, Xiaomei(gongxiaomei1981@163.com) ; Sun, Xiaojiang(sxj5191@126.com) ; Xu, Yaping(xuyaping1207@163.com)
英文摘要	Background: Radiographic changes after stereotactic body radiation therapy (SBRT) have not been well studied. The purpose of this study was to investigate the computed tomography (CT) appearance pattern of radiation-induced lung injury (RILI) and recurrence after SBRT in patients with early stage non-small cell lung cancer (NSCLC). Methods: We retrospectively analyzed clinical data of inoperable early stage NSCLC patients undergoing SBRT treatment from February 2012 to June 2018. All patients had undergone serial CT scanning before SBRT and after completion of SBRT. An experienced radiation oncologist and radiologist reviewed all CT images, and identified the RILI and CT high-risk features (HRFs). Results: A total of 60 patients were enrolled in this study; 55 patients had RILI (91.67%) and 7 patients had local failure. In the early CT findings of observers 1 and 2, there were diffuse ground glass opacities (GGOs) in 3 and 4 patients, diffuse consolidation in 10 and 12 patients, patchy consolidation in 22 and 15 patients, patchy GGOs in 19 and 24 patients, and no changes in 5 and 4 patients, respectively (kappa =0.706). In the late CT findings of observer 1 and 2, there were modified conventional patterns in 37 and 37 patients, mass-like patterns in 10 and 9 patients, scar-like patterns in 7 and 8 patients, and no changes in 5 and 5 patients, respectively (kappa =0.726). In the results of the CT-based HRFs of disease local failure, there were >= 1 HRFs in 7 patients, >= 2 HRFs in 7 patients, >= 3 HRFs in 6 patients, >= 4 HRFs in 5 patients, and >= 5 HRFs in 3 patients, respectively. Patients with only 1 HRF showed high sensitivity (100%) and low specificity (52.80%), with the specificity increasing and the sensitivity decreasing as the number of HRFs increased. Conclusions: The agreement of the CT appearance on RILI between 2 observers was good. Regular follow-up and attention to HRFs are vital for better identifying RILI and local disease failure.
WOS关键词	ABLATIVE RADIOTHERAPY ; FOLLOW-UP
WOS研究方向	Oncology ; Respiratory System
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000547884300031
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/102973]
专题	中国科学院合肥物质科学研究院
通讯作者	Gong, Xiaomei; Sun, Xiaojiang; Xu, Yaping
作者单位	1.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, 1 Banshan East Rd, Hangzhou, Peoples R China 2.Tongji Univ, Shanghai Pulm Hosp, Dept Radiat Oncol, Sch Med, 507 Zhengmin Rd, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Qian,Liu, Yu,Su, Bin,et al. The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer[J]. TRANSLATIONAL LUNG CANCER RESEARCH,2020,9.
APA	Li, Qian.,Liu, Yu.,Su, Bin.,Zhao, Hongguang.,Lin, Qingren.,...&Xu, Yaping.(2020).The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer.TRANSLATIONAL LUNG CANCER RESEARCH,9.
MLA	Li, Qian,et al."The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer".TRANSLATIONAL LUNG CANCER RESEARCH 9(2020).