Cervical granulocytic sarcoma

	Cervical granulocytic sarcoma
刊名	CHINESE MEDICAL JOURNAL
	2013
卷号	126
ISSN号	0366-6999
其他题名	Cervical granulocytic sarcoma
英文摘要	To the editor: a 34 year-old (gravida one, para one) female with a 1-year history of menorrhagia diagnosed 5 days earlier with cervical cancer was admitted to our hospital on April 16th, 2009. Previous medical history and family history were not remarkable, and physical examination was normal. Gynecologic examination showed normal vagina with an 8 cm diameter hard cervical mass that bled easily. The uterus was normal and movable. No mass was found in the adnexal area. Lateral ligaments were not thickened. Ultrasound indicated cervical diameter was 5.9 cm with 5.7 cm × 5.8 cm low echo mass be identified. A cervical biopsy done after admission, the pathologic finding showed diffuse, medium-sized oval or round cells with high nuclear/cytoplasm ratio. Nuclei had an oval shape with weak basophilic staining and reticular-like chromatin with scantly distributed eosinophils. Nucleoli was small and immature. No cervical epithelial or glandular cells can be seen (Figure 1A). Immunohistochemical analyses showed myeloperoxidase (MPO) (+), synapsin (Syn) (-), chromogranin (CgA) (-), and T-cell surface markers CD3(-), CD20(-) (Figure 1B). A diagnosis of granulocytic sarcoma of cervix stage Ib2, immature type was made based on the pathologic findings. However, bone marrow biopsy and routine blood test were normal. Neoadjuvant chemotherapy was administered prior to surgery due to the large size of the tumor. Beginning on April 27, the patient was administered one course of neoadjuvant chemotherapy (Paclitaxel 180 mg plus Epirubicin 70 mg given intravenously). No obvious effect was observed after the first course of chemotherapy, so the chemotherapy regimen was changed. Next the patient received 3 courses of Cytarabine (Ara-C) 100 mg day 1?7, and Daunorubicin 60 mg day 1?3 on May 20, June 14, and July 10, respectively. After a total of 4 courses of chemotherapy, the tumor size was reduced dramatically. Gynecologic examination showed the cervix had a normal appearance with diameter of 3cm. Then radical hysterectomy with bilateral salpingectomy, right adnexal cyst removal and ovarian transposition was performed. During the operation, no abnormal tissue was observed in the muscularis layer and endometrium of uterus. The 3-cm cervix was rigid. No tumor cells were found in multiple postoperative cervix biopsies. No lymph node metastatses were found. A right ovarian vesicular cyst was diagnosed. Another 3 courses of chemotherapy with Ara-C and Daunorubicin were administered after surgery. The patient is currently in remission, with no evidence of relapse at the most recent follow-up examination.
语种	英语
CSCD记录号	CSCD:4928360
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/59935]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Cervical granulocytic sarcoma[J]. CHINESE MEDICAL JOURNAL,2013,126.
APA	(2013).Cervical granulocytic sarcoma.CHINESE MEDICAL JOURNAL,126.
MLA	"Cervical granulocytic sarcoma".CHINESE MEDICAL JOURNAL 126(2013).