LncRNAs in DNA damage response and repair in cancer cells

	LncRNAs in DNA damage response and repair in cancer cells
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2018
卷号	50
关键词	LONG NONCODING RNA CISPLATIN-INDUCED NEPHROTOXICITY STRAND BREAK REPAIR NASOPHARYNGEAL CARCINOMA HOMOLOGOUS RECOMBINATION MESENCHYMAL TRANSITION REPLICATION STRESS PANCREATIC-CANCER COLORECTAL-CANCER GENOME INTEGRITY DNA damage response apoptosis cell cycle cancer lncRNA
ISSN号	1672-9145
其他题名	LncRNAs in DNA damage response and repair in cancer cells
英文摘要	In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo-and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (lncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of lncRNAs in regulating the cellular response to DNA damage.
资助项目	[National Natural Science Foundation of China] ; [Hunan Provincial Natural Science Foundation of China] ; [Scientific Research Foundation of the Health and Family Planning Commission of Hunan Province]
语种	英语
CSCD记录号	CSCD:6252625
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/57966]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. LncRNAs in DNA damage response and repair in cancer cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50.
APA	(2018).LncRNAs in DNA damage response and repair in cancer cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50.
MLA	"LncRNAs in DNA damage response and repair in cancer cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50(2018).