Resistance to apoptosis should not be taken as a hallmark of cancer

	Resistance to apoptosis should not be taken as a hallmark of cancer
	Wang RuiAn 1; Li ZengShan 1; Yan QingGuo 1; Bian XiuWu 1; Ding YanQing 1; Du Xiang 2; Sun BaoCun 1; Sun YunTian 3; Zhang XiangHong 1
刊名	CHINESE JOURNAL OF CANCER
	2014
卷号	33
关键词	BREAST-CANCER PROGNOSTIC-SIGNIFICANCE BCL-2 EXPRESSION GROWTH TUMORIGENESIS REGULATORS MARKER CELLS Cancer apoptosis Bcl-2 hallmark
ISSN号	1000-467X
其他题名	Resistance to apoptosis should not be taken as a hallmark of cancer
英文摘要	In the research community, resistance to apoptosis is often considered a hallmark of cancer. However, pathologists who diagnose cancer via microscope often see the opposite. Indeed, increased apoptosis and mitosis are usually observed simultaneously in cancerous lesions. Studies have shown that increased apoptosis is associated with cancer aggressiveness and poor clinical outcome. Furthermore, overexpression of Bcl-2, an antiapoptotic protein, is linked with better survival of cancer patients. Conversely, Bax, CD95, Caspase-3, and other apoptosis-inducing proteins have been found to promote carcinogenesis. This notion of the role of apoptosis in cancer is not new; cancer cells were found to be short-lived 88 years ago. Given these observations, resistance to apoptosis should not be considered a hallmark of cancer.
语种	英语
CSCD记录号	CSCD:5085880
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/46582]
专题	中国科学院合肥物质科学研究院
作者单位	1.中国科学院大连化学物理研究所 2.复旦大学 3.中国科学院合肥物质科学研究院肿瘤医院
推荐引用方式 GB/T 7714	Wang RuiAn,Li ZengShan,Yan QingGuo,et al. Resistance to apoptosis should not be taken as a hallmark of cancer[J]. CHINESE JOURNAL OF CANCER,2014,33.
APA	Wang RuiAn.,Li ZengShan.,Yan QingGuo.,Bian XiuWu.,Ding YanQing.,...&Zhang XiangHong.(2014).Resistance to apoptosis should not be taken as a hallmark of cancer.CHINESE JOURNAL OF CANCER,33.
MLA	Wang RuiAn,et al."Resistance to apoptosis should not be taken as a hallmark of cancer".CHINESE JOURNAL OF CANCER 33(2014).