Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients

doi:10.1186/s12885-020-07277-3

	Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients
	Huo,Xingxing 1,2,3,4; Qi,Jian 1,2,3; Huang,Kaiquan 4; Bu,Su 4; Yao,Wei 4; Chen,Ying 4; Nie,Jinfu 1,2,3
刊名	BMC Cancer
	2020-08-17
卷号	20
关键词	Autophagy HCC Autophagy-related genes Molecular signature Drug sensitivity
DOI	10.1186/s12885-020-07277-3
通讯作者	Nie,Jinfu(jeffnie@cmpt.ac.cn)
英文摘要	AbstractBackgroundAutophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been proposed to play a pivotal role in the progression of hepatocellular carcinoma (HCC).MethodsUnivariate Cox regression analysis of overall survival (OS) was performed to identify risk-associated autophagy-related genes (ARGs) in HCC data set from The Cancer Genome Atlas (TCGA). Multivariate cox regression was then performed to develop a risk prediction model for the prognosis of 370 HCC patients. The multi-target receiver operating characteristic (ROC) curve was used to determine the model’s accuracy. Besides, the relationship between drug sensitivity and ARGs expression was also examined.ResultsA total of 62 differentially expressed ARGs were identified in HCC patients. Univariate and multivariate regression identified five risk-associated ARGs (HDAC1, RHEB, ATIC, SPNS1 and SQSTM1) that were correlated with OS in HCC patients. Of importance, the risk-associated ARGs were independent risk factors in the multivariate risk model including clinical parameters such as malignant stage (HR?=?1.433, 95% CI?=?1.293–1.589, P?
资助项目	100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China[81803938] ; Anhui University of Traditional Chinese Medicine Natural Science Foundation[2018zryb48] ; Anhui University of Traditional Chinese Medicine Natural Science Foundation[2019zryb12]
WOS关键词	POOR-PROGNOSIS ; HDAC1 EXPRESSION ; PROLIFERATION ; PROGRESSION ; METASTASIS ; TUMOR ; SENSITIVITY ; ACTIVATION ; APOPTOSIS ; INVASION
WOS研究方向	Oncology
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12885-020-07277-3
资助机构	100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Anhui University of Traditional Chinese Medicine Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/42811]
专题	中国科学院合肥物质科学研究院
通讯作者	Nie,Jinfu
作者单位	1.University of Science and Technology of China 2.Hefei Cancer Hospital, Chinese Academy of Sciences 3.Hefei Institutes of Physical Science, Chinese Academy of Sciences; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology 4.the First Affiliated Hospital of Anhui University of Chinese Medicine; Experimental Center of Clinical Research
推荐引用方式 GB/T 7714	Huo,Xingxing,Qi,Jian,Huang,Kaiquan,et al. Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients[J]. BMC Cancer,2020,20.
APA	Huo,Xingxing.,Qi,Jian.,Huang,Kaiquan.,Bu,Su.,Yao,Wei.,...&Nie,Jinfu.(2020).Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients.BMC Cancer,20.
MLA	Huo,Xingxing,et al."Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients".BMC Cancer 20(2020).