Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

doi:10.1007/s10409-021-01057-3

	Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli
	Shu XY(舒芯钰)1,2,3; Li N(李宁)1,2,3; Wu Y(武亿)1,2,3; Li W(李旺)1,2,3; Zhang XY(张晓宇)1,2,3; Li PW(李培文)2,3; Lv DY(吕东媛)1,2,3; Lv SQ(吕守芹)1,2,3; Long M(龙勉)1,2,3
刊名	ACTA MECHANICA SINICA
	2021-03-10
页码	17
关键词	Liver sinusoidal endothelial cell Shear stress Mechanical stretch Extracellular matrix Stiffness
ISSN号	0567-7718
DOI	10.1007/s10409-021-01057-3
通讯作者	Li, Ning(lining_1@imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn)
英文摘要	Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed.
分类号	二类
资助项目	National Natural Science Foundation of China[91642203] ; National Natural Science Foundation of China[31627804] ; National Natural Science Foundation of China[31870930] ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences[GJJSTU20190005] ; Frontier Science Key Project of Chinese Academy of Sciences[QYZDJ-SSW-JSC018] ; Frontier Science Key Project of Chinese Academy of Sciences[XDB22040101]
WOS研究方向	Engineering ; Mechanics
语种	英语
WOS记录号	WOS:000627222700002
资助机构	National Natural Science Foundation of China ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/86293]
专题	力学研究所_国家微重力实验室
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China;
推荐引用方式 GB/T 7714	Shu XY,Li N,Wu Y,et al. Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli[J]. ACTA MECHANICA SINICA,2021:17.
APA	舒芯钰.,李宁.,武亿.,李旺.,张晓宇.,...&龙勉.(2021).Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli.ACTA MECHANICA SINICA,17.
MLA	舒芯钰,et al."Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli".ACTA MECHANICA SINICA (2021):17.