Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes

doi:10.1021/acs.nanolett.9b04596

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	Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
	Li L(李龙)4,6; Hu JL 3,5; Rozycki B 2; Song F(宋凡)1,4,6
刊名	NANO LETTERS
	2020-01
卷号	20 期号:1 页码:722-728
关键词	cell membrane adhesion receptor proteins nanoscale lipid clusters thermal fluctuations Monte Carlo simulations
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.9b04596
英文摘要	Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes.
分类号	一类
资助项目	National Key Research and Development Program of China[2016YFA0501601] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland[2016/21/B/NZ1/00006]
WOS关键词	LIPID RAFTS ; ANCHORED RECEPTORS ; MOLECULES ; ADHESION ; MYSTERY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000507151600094
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland
其他责任者	Hu, Jinglei
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/81294]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, PL-02668 Warsaw, Poland; 3.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China; 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 5.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210023, Peoples R China; 6.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China;
推荐引用方式 GB/T 7714	Li L,Hu JL,Rozycki B,et al. Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes[J]. NANO LETTERS,2020,20(1):722-728.
APA	Li L,Hu JL,Rozycki B,&Song F.(2020).Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.NANO LETTERS,20(1),722-728.
MLA	Li L,et al."Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes".NANO LETTERS 20.1(2020):722-728.