Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway | |
Wu XS9,10; Hu JR(胡锦荣)6,7,8; Li GQ10; Li Y1,10; Li Y10; Zhang J10; Wang F5,10; Li A4,10; Hu L10; Fan ZP10 | |
刊名 | EMBO JOURNAL |
2020-02-03 | |
卷号 | 39期号:3页码:19 |
关键词 | biomechanics organ replacement stress Wnt signaling |
ISSN号 | 0261-4189 |
DOI | 10.15252/embj.2019102374 |
英文摘要 | Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but the mechanism that initiates each cycle remains largely unknown. In a miniature pig model of tooth development that resembles tooth development in humans, the permanent tooth did not begin transitioning from the resting to the initiation stage until the deciduous tooth began to erupt. This eruption released the accumulated mechanical stress inside the mandible. Mechanical stress prevented permanent tooth development by regulating expression and activity of the integrin beta 1-ERK1-RUNX2 axis in the surrounding mesenchyme. We observed similar molecular expression patterns in human tooth germs. Importantly, the release of biomechanical stress induced downregulation of RUNX2-wingless/integrated (Wnt) signaling in the mesenchyme between the deciduous and permanent tooth and upregulation of Wnt signaling in the epithelium of the permanent tooth, triggering initiation of its development. Consequently, our findings identified biomechanical stress-associated Wnt modulation as a critical initiator of organ renewal, possibly shedding light on the mechanisms of integumentary organ regeneration. |
分类号 | 一类 |
资助项目 | Chinese Academy of Medical Sciences Research Unit[2019RU020] ; Capital Medical University, Beijing Municipality Government[PXM2018_014226_000021] ; Capital Medical University, Beijing Municipality Government[PXM2017_014226_000023] ; Capital Medical University, Beijing Municipality Government[PXM2018_193312_000006_0028S643_FCG PXM2016_014226_000034] ; Capital Medical University, Beijing Municipality Government[PXM2016_014226_000006] ; Capital Medical University, Beijing Municipality Government[PXM2015_014226_000116] ; Capital Medical University, Beijing Municipality Government[PXM2015_ 014226_000055] ; Capital Medical University, Beijing Municipality Government[PXM2015_014226_000052] ; National Natural Science Foundation of China[91649124] ; National Natural Science Foundation of China[81400478] ; National Natural Science Foundation of China[31661143044] ; National Natural Science Foundation of China[PXM2014_014226_000048] ; National Natural Science Foundation of China[PXM2014_014226_000013] ; National Natural Science Foundation of China[PXM2014_014226_000053] ; National Natural Science Foundation of China[Z121100005212004] ; National Natural Science Foundation of China[PXM2013_014226_000055] ; National Natural Science Foundation of China[PXM2013_014226_000021] ; National Natural Science Foundation of China[TJSHG201310025005] |
WOS关键词 | DENTAL LAMINA ; DIFFERENTIAL GROWTH ; ARTICULAR-CARTILAGE ; MECHANICAL TENSION ; WNT ; REGENERATION ; DENTITION ; TEETH ; IDENTIFICATION ; CONTRIBUTES |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000502188700001 |
资助机构 | Chinese Academy of Medical Sciences Research Unit ; Capital Medical University, Beijing Municipality Government ; National Natural Science Foundation of China |
其他责任者 | Wang, Songlin |
内容类型 | 期刊论文 |
源URL | [http://dspace.imech.ac.cn/handle/311007/81232] |
专题 | 力学研究所_国家微重力实验室 |
作者单位 | 1.Fortune Link Triones Scitech Co Ltd, Beijing, Peoples R China; 2.Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing, Peoples R China 3.Weifang Med Univ, Dept Stomatol, Yidu Cent Hosp, Weifang, Peoples R China; 4.Xi An Jiao Tong Univ, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Coll Stomatol, Xian, Shaanxi, Peoples R China; 5.Dalian Med Univ, Sch Stomatol, Dept Oral Basic Sci, Dalian, Peoples R China; 6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China; 7.Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing, Peoples R China; 8.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing, Peoples R China; 9.Cent S Univ, Xiangya Hosp, Dept Oral & Maxillofacial Surg, Changsha, Hunan, Peoples R China; 10.Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Beijing, Peoples R China; |
推荐引用方式 GB/T 7714 | Wu XS,Hu JR,Li GQ,et al. Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway[J]. EMBO JOURNAL,2020,39(3):19. |
APA | Wu XS.,Hu JR.,Li GQ.,Li Y.,Li Y.,...&Wang SL.(2020).Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway.EMBO JOURNAL,39(3),19. |
MLA | Wu XS,et al."Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway".EMBO JOURNAL 39.3(2020):19. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论