Infrared Skin-Like Active Stretchable Electronics Based on Organic-Inorganic Composite Structures for Promotion of Cutaneous Wound Healing

doi:10.1002/admt.201900150

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Infrared Skin-Like Active Stretchable Electronics Based on Organic-Inorganic Composite Structures for Promotion of Cutaneous Wound Healing
	Zhang LJ(张丽娟); Jiang XX; Jiang W; Li S(李爽); Chi YX; Liu H; Zhang MY; Li JY(李居耀); Fang M; Pan B
刊名	ADVANCED MATERIALS TECHNOLOGIES
	2019-08-01
卷号	4 期号:8 页码:10
关键词	cutaneous wound healing fibroblast proliferation inflammation inhibition near infrared therapy stretchable electronics
ISSN号	2365-709X
DOI	10.1002/admt.201900150
通讯作者	Li, Rui(ruili@dlut.edu.cn) ; Guo, Liang(guoliang@imech.ac.cn) ; Su, Yewang(yewangsu@imech.ac.cn)
英文摘要	Recent studies on flexible/stretchable medical electronics are almost all focusing on passive monitoring of physiological signs for medical diagnostics, but rare reports have been found on those for active therapeutic purposes. Here, a novel infrared skin-like active stretchable electronics (ISASE) is introduced with the organic-inorganic composite design for promotion of cutaneous wound healing, which can be conformally mounted anywhere on the human body due to its excellent flexibility and stretchability. Comprehensive experiments, including the proliferation and migration of human skin fibroblasts and rat dermal fibroblasts in vitro, and various tests on wound healing of rats, show favorable effects of the ISASE on promoting the fibroblast migration and proliferation, reducing the inflammatory phase, stimulating the angiogenesis, and shorting the wound healing period. A typical ISASE significantly shortens the cure time for a wounded rat by at least two days compared with the normal treatment with 12 days cure. The mechanical tests confirm the validity of the ISASE when used in extreme large deformations (e.g., stretched by up to 80% strain), which enables the conformability with the human body. The present portable and wearable ISASE demonstrates great potential for cutaneous wound healing, which constitutes an important complement to the current applications in the healthcare field.
分类号	二类/Q1
资助项目	National Natural Science Foundation of China[11772331] ; National Natural Science Foundation of China[11572323] ; National Natural Science Foundation of China[11302038] ; Chinese Academy of Sciences via the Hundred Talent Program, Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040501] ; Young Elite Scientists Sponsorship Program by CAST[2015QNRC001] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics, Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities of China[DUT18GF101] ; National Key Research and Development Plan[2016YFB0201600] ; National Key Research and Development Plan[2016YFB0201601] ; National Key Research and Development Plan[2017YFB0202800] ; National Key Research and Development Plan[2017YFB0202802] ; Program for Changjiang Scholars, Innovative Research Team in University (PCSIRT) ; 111 Project[B14013]
WOS关键词	LASER IRRADIATION ; 3RD-DEGREE BURNS ; RED LASER ; ULTRASOUND ; THERAPY ; PHOTOTHERAPY ; ACTIVATION ; SOFT
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000479301700010
资助机构	National Natural Science Foundation of China ; Chinese Academy of Sciences via the Hundred Talent Program, Strategic Priority Research Program of the Chinese Academy of Sciences ; Young Elite Scientists Sponsorship Program by CAST ; Opening Fund of State Key Laboratory of Nonlinear Mechanics, Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities of China ; National Key Research and Development Plan ; Program for Changjiang Scholars, Innovative Research Team in University (PCSIRT) ; 111 Project
其他责任者	Li, Rui ; Guo, Liang ; Su, Yewang
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/79769]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Zhang LJ,Jiang XX,Jiang W,et al. Infrared Skin-Like Active Stretchable Electronics Based on Organic-Inorganic Composite Structures for Promotion of Cutaneous Wound Healing[J]. ADVANCED MATERIALS TECHNOLOGIES,2019,4(8):10.
APA	张丽娟.,Jiang XX.,Jiang W.,李爽.,Chi YX.,...&苏业旺.(2019).Infrared Skin-Like Active Stretchable Electronics Based on Organic-Inorganic Composite Structures for Promotion of Cutaneous Wound Healing.ADVANCED MATERIALS TECHNOLOGIES,4(8),10.
MLA	张丽娟,et al."Infrared Skin-Like Active Stretchable Electronics Based on Organic-Inorganic Composite Structures for Promotion of Cutaneous Wound Healing".ADVANCED MATERIALS TECHNOLOGIES 4.8(2019):10.