hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol

	hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol
	Guo Yuanheng 1; Cao Lili 1; Zhao Bing 1; Zhao Qingsheng1 ; Huang Yuanrong 2; Xiao Chuanming 2
刊名	食品科学
	2018
卷号	39 期号:13 页码:176
ISSN号	1002-6630
英文摘要	The aim of this paper is to explore the hepatoprotective effect of Herba Cistanchis against alcohol-induced chronic hepatic injury and its underlying mechanism. Phenylethanoid glycosides (PhGs) were extracted and purified from Cistanche deserticola. Then, the PhGs composition was analyzed and the antioxidant activity was determined. The hepatoprotective activity was studied both in vitro and in vivo. In vitro, the survival of HepG2 cells was promoted by PhGs. In vivo, PhGs restored the alterations induced by alcohol, including serological indexes (alanine aminotransaminase, aspartate aminotransferase, γ-glutamyltranspeptidase, acid phosphatase, triglyceride and low density lipoprotein-cholesterol) and hepatic indicators (superoxide dismutase, glutathione S-transferase, glutathione, glutathione peroxidase, malondialdehyde and triglyceride) levels. The prominent microvesicular steatosis and necrosis in hepatic histopathology of model animals were also notably attenuated by PhGs administration. These results indicated that PhGs possess hepatoprotective properties against chronic alcohol-induced liver injury, the mechanisms involve the modulation of related enzyme (including superoxide dismutase, glutathione S-transferase, glutathione peroxidase) activities and the reduction of lipid peroxidation products such as malondialdehyde.
语种	英语
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/33537]
专题	中国科学院过程工程研究所
作者单位	1.中国科学院过程工程研究所 2.Beijing Keepyoung Technology Co. Ltd.
推荐引用方式 GB/T 7714	Guo Yuanheng,Cao Lili,Zhao Bing,et al. hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol[J]. 食品科学,2018,39(13):176.
APA	Guo Yuanheng,Cao Lili,Zhao Bing,Zhao Qingsheng,Huang Yuanrong,&Xiao Chuanming.(2018).hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol.食品科学,39(13),176.
MLA	Guo Yuanheng,et al."hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol".食品科学 39.13(2018):176.