A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation

doi:10.1039/c9sc02674f

	A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation
	Pan, Houhe 1; Li, Shukun 3; Kan, Jing-lan 2; Gong, Lei 1; Lin, Chenxiang 1; Liu, Wenping 1; Qi, Dongdong 1; Wang, Kang 1; Yan, Xuehai 3; Jiang, Jianzhuang 1
刊名	CHEMICAL SCIENCE
	2019-09-21
卷号	10 期号:35 页码:8246-8252
ISSN号	2041-6520
DOI	10.1039/c9sc02674f
英文摘要	Photothermal therapy in the second near-infrared window (NIR-II, 1000-1700 nm) exhibits a significant advantage over the first near-infrared window (NIR-I, 650-950 nm) in terms of both maximum permissible exposure (MPE) and penetration depth. However, the thus far reported NIR-II photothermal agents (PTAs) have been focused just on inorganic semiconducting and organic polymeric semiconducting nanoparticles. Herein a novel cruciform phthalocyanine pentad was designed, synthesized, and characterized for the first time. The water-soluble nanoparticles (Zn-4-H2Pc/DP NPs) assembled from this single molecular material with the help of DSPE-PEG(2000)-OCH3 exhibit characteristic absorption in the NIR-II region at 1064 nm with a large extinction coefficient of 52 L g(-1) cm(-1), high photothermal conversion efficiency of 58.3%, and intense photoacoustic signal. Moreover, both in vitro and in vivo studies reveal the good biocompatibility and notable tumor ablation ability of Zn-4-H2Pc/DP NPs under 1064 nm laser irradiation. Theoretical density functional theory calculations interpret the two-dimensional compressional wave energy-dissipation pathway over the broad saddle curved framework of the cruciform conjugated phthalocyanine pentad, rationalizing the efficient photothermal properties of corresponding Zn-4-H2Pc/DP NPs in the NIR-II window.
资助项目	Natural Science Foundation of China[21631003] ; Natural Science Foundation of China[21671017] ; Natural Science Foundation of China[21871024] ; Fundamental Research Funds for the Central Universities[FRF-BD-17016A] ; University of Science and Technology Beijing
WOS关键词	CONVERSION EFFICIENCY ; NANOPARTICLES ; THERAPY
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000486045200019
资助机构	Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; University of Science and Technology Beijing
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/30887]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai; Jiang, Jianzhuang
作者单位	1.Univ Sci & Technol Beijing, Dept Chem, Beijing Key Lab Sci & Applicat Funct Mol & Crysta, Beijing 100083, Peoples R China 2.Shandong Normal Univ, Minist Educ, Key Lab Mol & Nano Probes, Jinan 250014, Shandong, Peoples R China 3.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Pan, Houhe,Li, Shukun,Kan, Jing-lan,et al. A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation[J]. CHEMICAL SCIENCE,2019,10(35):8246-8252.
APA	Pan, Houhe.,Li, Shukun.,Kan, Jing-lan.,Gong, Lei.,Lin, Chenxiang.,...&Jiang, Jianzhuang.(2019).A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation.CHEMICAL SCIENCE,10(35),8246-8252.
MLA	Pan, Houhe,et al."A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation".CHEMICAL SCIENCE 10.35(2019):8246-8252.