Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth | |
Zhang, S (Zhang, Sheng)[ 1 ]; Liu, FZ (Liu, Feize)[ 2,3 ]; Hou, XL (Hou, Xueling)[ 2 ]; Cao, JG (Cao, Jianguo)[ 1 ]; Dai, XL (Dai, Xiling)[ 1 ]; Yu, JJ (Yu, Junjie)[ 1 ]; Huang, GZ (Huang, Guozheng)[ 1,2 ] | |
刊名 | BIOMOLECULES |
2019 | |
卷号 | 9期号:10页码:1-10 |
关键词 | thienopyrimidine thieno[2,3-d] pyrimidinone anticancer |
ISSN号 | 2218-273X |
DOI | 10.3390/biom9100631 |
英文摘要 | New 2,3-disubstituted thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized via a one-pot reaction from 2H-thieno[2,3-d] [1,3]oxazine-2,4(1H)-diones, aromatic aldehydes, and benzylamine or 4-hydroxylbezylamine. The obtained compounds were tested in vitro for cancer cell growth inhibition. Compound 19 can inhibit all four types of tested cancer cells, i.e., MCF-7, A549, PC-9, and PC-3 cells. Most of the compounds inhibited the proliferation of A549 and MCF-7 cells. Compound 15 exhibited the strongest anti-proliferative effect against A549 cell lines with IC50 values of 0.94 mu M, and with no toxicity to normal human liver cells. Its potency was further proved by cell clone formation assay, Hoechst 33258 staining, and evaluation on the effects of apoptosis-related proteins. |
WOS记录号 | WOS:000497726800123 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7207] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 3.Shanghai Normal Univ, Coll Life Sci, Shanghai 201418, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, S ,Liu, FZ ,Hou, XL ,et al. Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth[J]. BIOMOLECULES,2019,9(10):1-10. |
APA | Zhang, S .,Liu, FZ .,Hou, XL .,Cao, JG .,Dai, XL .,...&Huang, GZ .(2019).Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth.BIOMOLECULES,9(10),1-10. |
MLA | Zhang, S ,et al."Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth".BIOMOLECULES 9.10(2019):1-10. |
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