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	Structural Studies of G Protein-Coupled Receptors
	Zhang, Dandan; Zhao, Qiang; Wu, Beili
刊名	MOLECULES AND CELLS
	2015-10
卷号	38期号:10页码:836-842
关键词	activation allosteric modulation GPCR ligand recognition structure
ISSN号	1016-8478
DOI	10.14348/molcells.2015.0263
文献子类	Review
英文摘要	G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
资助项目	CAS Strategic Priority Research Program[XDB08020300] ; National Science Foundation of China[31422017] ; National Science Foundation of China[31370729]
WOS关键词	MUSCARINIC ACETYLCHOLINE-RECEPTOR ; RESOLUTION CRYSTAL-STRUCTURE ; A(2A) ADENOSINE RECEPTOR ; HUMAN P2Y(12) RECEPTOR ; OPIOID RECEPTOR ; SEROTONIN RECEPTORS ; MEMBRANE-PROTEINS ; COMPLEX ; GPCR ; ANTAGONIST
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
WOS记录号	WOS:000364586200002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276377]
专题	药物靶标结构与功能中心
通讯作者	Wu, Beili
作者单位	Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dandan,Zhao, Qiang,Wu, Beili. Structural Studies of G Protein-Coupled Receptors[J]. MOLECULES AND CELLS,2015,38(10):836-842.
APA	Zhang, Dandan,Zhao, Qiang,&Wu, Beili.(2015).Structural Studies of G Protein-Coupled Receptors.MOLECULES AND CELLS,38(10),836-842.
MLA	Zhang, Dandan,et al."Structural Studies of G Protein-Coupled Receptors".MOLECULES AND CELLS 38.10(2015):836-842.

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