BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS

doi:10.3987/REV-15-825

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS
	Wang, Jing 1; Tang, Jie 1; Yu, Li-Fang 1; Li, Jia2 ; Li, Jing-Ya2 ; Yang, Fan 1
刊名	HETEROCYCLES
	2015-12-01
卷号	91 期号:12 页码:2233-2270
ISSN号	0385-5414
DOI	10.3987/REV-15-825
文献子类	Article
英文摘要	The promising activities shown by analogues of natural product berberine in numerous categories such as anti-hyperglycaemic, anti-cancer, anti-inflammatory, anti-alzheimer's disease and anti-microbials, have made it an indispensable structure for development of new therapeutic agents. The compounds bearing various substituents on the berberine skeleton have exhibited a wide spectrum of biological activities. Short reviews on biological importance of this core structure have been showcased in literature. However, systematic review on the research advances of structure-activity relationship of berberine and its analogues seems lacking. In the present review, various analogues of berberine with different pharmacological activities were summarized and their SAR were discussed as well. The current review would provide useful information for further studies on structural modifications on berberine for discovering new drug leads.
资助项目	China National Science and Technology[2015BAK45B00] ; Shanghai Science and Technology Council[14142201200] ; Shanghai Science and Technology Council[14DZ0511800] ; Shanghai Science and Technology Council[13ZR1410600] ; National Science and Technology Major Projects for Major New Drugs Innovation and Development[2013ZX09507002] ; National Science Fund for Distinguished Young Scholars[81125023] ; Laboratory of Organic Functional Molecules, Sino-French Institute of ECNU[00000000]
WOS关键词	QUADRUPLEX STABILIZING LIGANDS ; DNA-BINDING AFFINITIES ; RECEPTOR UP-REGULATORS ; DOUBLE-STRANDED DNA ; IN-VITRO ; MULTIFUNCTIONAL AGENTS ; BIOLOGICAL EVALUATION ; ALZHEIMERS-DISEASE ; BERBERRUBINE DERIVATIVES ; PROTOBERBERINE ALKALOIDS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000369356300001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276293]
专题	国家新药筛选中心药物安全性评价中心
通讯作者	Wang, Jing
作者单位	1.E China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, SCME, Shanghai 200062, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jing,Tang, Jie,Yu, Li-Fang,et al. BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS[J]. HETEROCYCLES,2015,91(12):2233-2270.
APA	Wang, Jing,Tang, Jie,Yu, Li-Fang,Li, Jia,Li, Jing-Ya,&Yang, Fan.(2015).BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS.HETEROCYCLES,91(12),2233-2270.
MLA	Wang, Jing,et al."BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS".HETEROCYCLES 91.12(2015):2233-2270.