Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by alpha-Diazotized Meldrum's Acid

doi:10.1002/ejoc.201601212

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	Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by alpha-Diazotized Meldrum's Acid
	Lv, Honggui 1,2; Xu, William L.2; Lin, Kunhua 1; Shi, Jingjing2 ; Yi, Wei
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2016-12
期号	34 页码:5637-5641
关键词	C-H activation Carbenoids Insertion Iridium Regioselectivity
ISSN号	1434-193X
DOI	10.1002/ejoc.201601212
文献子类	Article
英文摘要	A practical and straightforward protocol for Ir-III-catalyzed regioselective carbenoid insertion C-H alkylation mediated by alpha-diazotized Meldrum's acid was developed. The assistance of external additives and oxidants was not needed, and the developed Ir-III catalysis proceeds in a highly efficient manner (e.g., mild reaction conditions, short reaction times and excellent regioselectivity) and demonstrates good compatibility with several privileged substrates, such as valuable N-(2-pyrimidyl) indoles, phenylpyridines, and the marketed drug edaravone and its analogues, and thus provides a good complement to previous methods for the rapid construction of the corresponding alkylated products.
资助项目	Youth Innovation Promotion Association CAS[00000000] ; Sanofi-SIBS Yong Faculty Award[00000000] ; National Natural Science Foundation of China[81502909] ; Shanghai Municipal Natural Science Foundation[15ZR1447800]
WOS关键词	RHODIUM(III)-CATALYZED ORTHO-ALKENYLATION ; BOND-FORMING REACTIONS ; DIAZOCARBONYL COMPOUNDS ; N BOND ; PPAR-GAMMA ; CHELATION-ASSISTANCE ; MIGRATORY INSERTION ; ROOM-TEMPERATURE ; DIRECTING GROUPS ; FACILE SYNTHESIS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000390760000008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275777]
专题	药物靶标结构与功能中心
通讯作者	Shi, Jingjing
作者单位	1.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China; 2.Chinese Acad Sci, VARI SIMM Ctr, Ctr Struct & Funct Drug Targets, CAS Key Lab Receptor Res,Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Lv, Honggui,Xu, William L.,Lin, Kunhua,et al. Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by alpha-Diazotized Meldrum's Acid[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2016(34):5637-5641.
APA	Lv, Honggui,Xu, William L.,Lin, Kunhua,Shi, Jingjing,&Yi, Wei.(2016).Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by alpha-Diazotized Meldrum's Acid.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(34),5637-5641.
MLA	Lv, Honggui,et al."Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by alpha-Diazotized Meldrum's Acid".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .34(2016):5637-5641.