An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)

doi:10.1016/j.clinre.2017.02.001

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	An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)
	Xiao, Ling 1,2; Pan, Guoyu1,2
刊名	CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
	2017-10
卷号	41 期号:5 页码:509-515
ISSN号	2210-7401
DOI	10.1016/j.clinre.2017.02.001
文献子类	Review
英文摘要	The enterohepatic circulation of bile acids (BAs) is governed by specific transporters expressed in the liver and the intestine and plays a critical role in the digestion of fats and oils. During this process, the majority of the BAs secreted from the liver is reabsorbed in intestinal epithelial cells via the apical sodium-dependent bile acid transporter (ASBT/SLC10A2) and then transported into the portal vein. Previous studies revealed that regulation of the ASBT involves BAs and cholesterol. In addition, abnormal ASBT expression and function might lead to some diseases associated with disorders in the enterohepatic circulation of BAs and cholesterol homeostasis, such as diarrhoea and gallstones. However, decreasing cholesterol or BAs by partly inhibiting ASBT-mediated transport might be used for treatments of hypercholesterolemia, cholestasis and diabetes. This review mainly discusses the regulation of the ASBT by BAs and cholesterol and its relevance to diseases and treatment. (C) 2017 Elsevier Masson SAS. All rights reserved.
资助项目	National Natural Science Foundation of China[81302836] ; National Natural Science Foundation of China[81573499] ; National High Technology Research and Development Program of China[2013AA032202]
WOS关键词	INFLAMMATORY-BOWEL-DISEASE ; NUCLEAR RECEPTOR ; DOWN-REGULATION ; OBSTRUCTIVE CHOLESTASIS ; ILEAL INFLAMMATION ; DIABETES-MELLITUS ; GALLSTONE DISEASE ; BINDING PROTEIN ; MESSENGER-RNA ; GENE SLC10A2
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	ELSEVIER MASSON
WOS记录号	WOS:000414206200009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272465]
专题	药物安全性评价中心
通讯作者	Pan, Guoyu
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai, Peoples R China;
推荐引用方式 GB/T 7714	Xiao, Ling,Pan, Guoyu. An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)[J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY,2017,41(5):509-515.
APA	Xiao, Ling,&Pan, Guoyu.(2017).An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT).CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY,41(5),509-515.
MLA	Xiao, Ling,et al."An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)".CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY 41.5(2017):509-515.