One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization

doi:10.1039/c7ob01977g

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	One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization
	Lv, Honggui 1,2,3,4; Shi, Jingjing4 ; Wu, Bo 1,2; Guo, Yujuan 1,2; Huang, Junjun 1,2; Yi, Wei 1,2,4
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2017-10-14
卷号	15 期号:38 页码:8054-8058
ISSN号	1477-0520
DOI	10.1039/c7ob01977g
文献子类	Article
英文摘要	Reported herein is the first Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization of N-arylureas and alpha-diazo beta-keto esters. The redox-neutral reaction has the following features: good to excellent yields, broad substrate/functional group tolerance, exclusive regioselectivity, and no need for additional oxidants or additives, which render this methodology as a more efficient and versatile alternative to the existing methods for the synthesis of 2,3-difunctionalized indoles.
资助项目	NSFC[81502909]
WOS关键词	DIAZO CARBONYL-COMPOUNDS ; N BOND-CLEAVAGE ; DIRECTING GROUP ; REGIOSELECTIVE SYNTHESIS ; MIGRATORY INSERTION ; UNPROTECTED INDOLES ; EFFICIENT SYNTHESIS ; INTERNAL ALKYNES ; ROOM-TEMPERATURE ; ARYL UREAS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000412826500011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272450]
专题	药物靶标结构与功能中心
通讯作者	Yi, Wei
作者单位	1.Guangzhou Med Univ, Key Lab Mol Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China; 2.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; 3.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China 4.Chinese Acad Sci, CAS Key Lab Receptor Res, VARI SIMM Ctr, Ctr Struct & Funct Drug Targets,Shanghai Inst Mat, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Lv, Honggui,Shi, Jingjing,Wu, Bo,et al. One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(38):8054-8058.
APA	Lv, Honggui,Shi, Jingjing,Wu, Bo,Guo, Yujuan,Huang, Junjun,&Yi, Wei.(2017).One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization.ORGANIC & BIOMOLECULAR CHEMISTRY,15(38),8054-8058.
MLA	Lv, Honggui,et al."One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization".ORGANIC & BIOMOLECULAR CHEMISTRY 15.38(2017):8054-8058.