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	3D Structural Investigation of Solid Dosage Forms
	Yin, Xianzhen2,3; Wu, Li2,4; He, You1; Guo, Zhen2,3; Ren, Xiaohong2,4; Shao, Qun3; Gu, Jingkai4; Xiao, Tiqiao1; York, Peter3; Zhang, Jiwen2,4
	2015-05-23
出处	Computational Pharmaceutics: Application of Molecular Modelling in Drug Delivery
出版者	wiley
页码	235-262
英文摘要	Drug substances and other nonactive formulation ingredients exist in the majority of solid dosage forms as dry powders or crystals and solid dispersions in particle size ranging from nanocolloids to millimeter-sized granules. Electron microscopy (SEM and TEM) is the most widely used method to observe the surface structures of pharmaceutical dosage forms and powders, such as the morphology, particle size distribution, and thermal properties of microcapsules. Though the image analysis of 2D observations in some cases can give some quantitative information, a real in situ 3D structural investigation method is important to achieve a real understanding of the internal microstructure of pharmaceutical dosage forms. Fractal analysis, especially architectural fractal analysis, was initially employed in this work to characterize the internal structural changes taking place during drug release that cannot be measured by conventional methods.
DOI标识	10.1002/9781118573983.ch12
语种	英语
文献子类	Book Chapter
内容类型	专著章节
源URL	[http://119.78.100.183/handle/2S10ELR8/266839]
专题	分子影像中心（筹）
通讯作者	Yin, Xianzhen
作者单位	1.Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; 3.Institute of Pharmaceutical Innovation, University of Bradford, United Kingdom; 4.Research Center for Drug Metabolism, Jilin University, China
推荐引用方式 GB/T 7714	Yin, Xianzhen,Wu, Li,He, You,et al. 3D Structural Investigation of Solid Dosage Forms:wiley,2015:235-262.

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