Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats

doi:10.1055/s-0029-1185669

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats
	Jiang, Baohong; Wu, Wanying; Li, Ming; Xu, Lingling; Sun, Kejia; Yang, Min; Guan, Shuhong; Liu, Xuan; Guo, De-an
刊名	PLANTA MEDICA
	2009-10
卷号	75 期号:12 页码:1286-1292
关键词	Salvia miltiorrhiza Labiatae salvianolic acids acute myocardial infarction matrix metalloproteinase-9 cardioprotection
ISSN号	0032-0943
DOI	10.1055/s-0029-1185669
文献子类	Article
英文摘要	Acute myocardial infarction (AMI) remains the leading cause of mortality in the world. Early intervention using salvianolic acids (SA) can substantially improve clinical outcomes. However, in spite of the great achievements that have been made in elucidating the protective effects of SA on AMI the effects of SA on the contractile performance of the left ventricle (LV) and the underlying mechanism are still not so clear. In the present study, AMI was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Administration of SA significantly decreased infarct size, improved LV function and appearance of the myocardium and decreased myocardial malondialdehyde levels compared with the AMI group. Furthermore, treatment with SA significantly downregulated the mRNA expression level and activity of matrix metalloproteinase-9 (MMP-9), but did not regulate the tissue inhibitor of metalloproteinase-1 (TIMP-1) expression level at the infarct area. Lisinopril (an angiotensin converting enzyme inhibitor), which holds potential effects on cardioprotection, was chosen as the positive control in this study. Lisinopril elevated LV function and appearance of the myocardium, decreased malondialdehyde levels without an influence on infarct size, and regulated the MMP-9 enzyme level but not the MMP-9 mRNA and TIMP-1 protein levels. These findings suggest that early SA treatment is effective to improve LV function; and SA may exert preventative effects against myocardial remodeling after infarction.
资助项目	International Science and Technology Cooperation[2006DFB31860] ; Ministry of Science and Technology of China[2006BA1081303-03]
WOS关键词	MATRIX METALLOPROTEINASES ; CELLS ; EXPRESSION ; MICE ; SUPPRESSION ; INHIBITION ; INDUCTION ; STRESS ; HEART ; MMP-9
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000271098300002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279120]
专题	上海中药现代化研究中心
通讯作者	Guo, De-an
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Baohong,Wu, Wanying,Li, Ming,et al. Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats[J]. PLANTA MEDICA,2009,75(12):1286-1292.
APA	Jiang, Baohong.,Wu, Wanying.,Li, Ming.,Xu, Lingling.,Sun, Kejia.,...&Guo, De-an.(2009).Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats.PLANTA MEDICA,75(12),1286-1292.
MLA	Jiang, Baohong,et al."Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats".PLANTA MEDICA 75.12(2009):1286-1292.