Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum

doi:10.1055/s-0029-1240796

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	Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum
	Lin, Hong-Wei 1; Sun, Ming-Xue 1; Wang, Yun-Hua 2; Yang, Liu-Meng 2; Yang, Ying-Ruo 2; Huang, Ning 2; Xuan, Li-Jiang3 ; Xu, Ya-Ming 3; Bai, Dong-Lu3 ; Zheng, Yong-Tang 2
刊名	PLANTA MEDICA
	2010-06
卷号	76 期号:9 页码:889-892
关键词	Polygonum cuspidatum Polygonum multiflorum Polygonaceae chemical components anti-HIV-1 activity
ISSN号	0032-0943
DOI	10.1055/s-0029-1240796
文献子类	Article
英文摘要	The 70% EtOH extract of Polygonum cuspidatum showed inhibitory action against HIV-1-induced syncytium formation at non-cytotoxic concentrations in vitro with a 50% effective concentration (EC50) of 13.94 +/- 3.41 mu g/mL. Through bioactivity-guided fractionation, 20 phenolic compounds, including eight stilbenoids, were isolated from the roots of Polygonum cuspidatum, and their anti-HIV-1 activities were evaluated. Results showed that compounds 1, 13, 14, and 16 demonstrated fairly strong antiviral activity against HIV-1-induced cytopathic effects in C8166 lymphocytes at non-cytotoxic concentrations, with EC50 values of 4.37 +/- 1.96 mu g/mL, 19.97 +/- 5.09, 14.4 +/- 1.34 mu g/mL, and 11.29 +/- 6.26 mu g/mL and therapeutic index (TI) values of 8.12, > 10.02, > 13.89, and > 17.71, respectively. Other compounds showed either weak or no effects. Compound 6 also showed weak inhibition (153.42 +/- 19.25 mu g/mL); however, it possesses very good water solubility and showed almost no cytotoxicity (> 2000 mu g/mL), therefore achieving a fairly good TI (13.04). The activities of the two compounds (3 and 18) from Polygonum multiflorum were also assayed. The relationship between molecular structures and their bioactivities was also discussed.
资助项目	National Natural Science Foundation of China[20872179] ; National Natural Science Foundation of China[30472141] ; Science and Technology Commission of Shanghai Municipality (STCSM)[08DZ1971504] ; Scientific and Technological Projects of China[2009ZX09501-029] ; Scientific and Technological Projects of China[2008ZX10005-005] ; 973 Program[2009CB522306] ; CAS[KSCX1-YW-R-24] ; CAS[KSCX2-YW-R-185]
WOS关键词	STILBENE GLYCOSIDES ; CONSTITUENTS ; INHIBITORS ; CELLS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000279668400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278893]
专题	上海中药现代化研究中心院士及顾问专家
通讯作者	Zheng, Yong-Tang
作者单位	1.Second Mil Med Univ, Lab Toxicol & Pharmacol, Fac Naval Med, Shanghai, Peoples R China; 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Lin, Hong-Wei,Sun, Ming-Xue,Wang, Yun-Hua,et al. Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum[J]. PLANTA MEDICA,2010,76(9):889-892.
APA	Lin, Hong-Wei.,Sun, Ming-Xue.,Wang, Yun-Hua.,Yang, Liu-Meng.,Yang, Ying-Ruo.,...&Xiao, Kai.(2010).Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum.PLANTA MEDICA,76(9),889-892.
MLA	Lin, Hong-Wei,et al."Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum".PLANTA MEDICA 76.9(2010):889-892.