Biomimetic Synthesis: Discovery of Xanthanolide Dimers

doi:10.1002/anie.201406461

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	Biomimetic Synthesis: Discovery of Xanthanolide Dimers
	Shang, Hai 3,4; Liu, Junhua 1; Bao, Ruiyang 3,4; Cao, Yu 5; Zhao, Kun 3,4; Xiao, Chengqian 1; Zhou, Bing5 ; Hu, Lihong 1; Tang, Yefeng 2,3,4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2014-12-22
卷号	53 期号:52 页码:14494-14498
关键词	biomimetic synthesis cycloaddition dimerization natural products photochemistry
ISSN号	1433-7851
DOI	10.1002/anie.201406461
文献子类	Article
英文摘要	Starting from xanthatin, the biomimetic synthesis of 4 beta,5 beta-epoxyxanthatin-1 alpha,4 alpha-endoperoxide, a novel monomeric xanthanolide, has been achieved. Moreover, four unprecedented xanthanolide dimers were synthesized by three different dimerizations of xanthatin, either in a head-to-head or head-to-tail fashion. Notably, these dimeric compounds were firstly identified as artifacts in the laboratory, and two of them, mogolides A and B, proved to be natural products present in the Xanthium mogolium Kitag plant.
资助项目	National Science Foundation of China[21102081] ; National Science Foundation of China[21272133] ; National Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Beijing Natural Science Foundation[2132037] ; Science Foundation of Shanghai[12XD1405700] ; China Postdoctoral Science Foundation[2014M550255] ; Tsinghua-Giti project[00000000]
WOS关键词	DIELS-ALDER REACTIONS ; CYTOTOXIC SESQUITERPENE LACTONES ; OCCURRING TERPENE DERIVATIVES ; PHOTOINDUCED POLAR ADDITION ; ATROP-ABYSSOMICIN-C ; XANTHIUM-STRUMARIUM ; PHOTOCHEMICAL-REACTIONS ; ABSOLUTE-CONFIGURATION ; 2+2 PHOTODIMERIZATION ; PROTIC SOLVENTS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000346485800035
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276796]
专题	上海中药现代化研究中心
通讯作者	Hu, Lihong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China 3.Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Comprehens AIDS Res Ctr, Beijing 100084, Peoples R China; 4.Tsinghua Univ, Collaborat Innovat Ctr Biotherapy, Beijing 100084, Peoples R China; 5.Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China;
推荐引用方式 GB/T 7714	Shang, Hai,Liu, Junhua,Bao, Ruiyang,et al. Biomimetic Synthesis: Discovery of Xanthanolide Dimers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(52):14494-14498.
APA	Shang, Hai.,Liu, Junhua.,Bao, Ruiyang.,Cao, Yu.,Zhao, Kun.,...&Tang, Yefeng.(2014).Biomimetic Synthesis: Discovery of Xanthanolide Dimers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(52),14494-14498.
MLA	Shang, Hai,et al."Biomimetic Synthesis: Discovery of Xanthanolide Dimers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.52(2014):14494-14498.