| Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid | |
| Hsu, Yuan-Man3; Hung, Yi-chih4,5; Hu, Lihong6; Lee, Yi-ju1; Yin, Mei-chin2,7 | |
| 刊名 | NUTRIENTS
 |
| 2015-12 | |
| 卷号 | 7期号:12页码:10065-10075 |
| 关键词 | madecassic acid rotundic acid diabetes coagulation anti-lipid |
| ISSN号 | 2072-6643 |
| DOI | 10.3390/nu7125512 |
| 文献子类 | Article |
| 英文摘要 | Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasminogen activator inhibitor-1 activity and fibrinogen level; as well as restored antithrombin-III and protein C activities in plasma of diabetic mice. MEA or RA intake decreased triglyceride and cholesterol levels in plasma and liver. Histological data agreed that MEA or RA intake lowered hepatic lipid droplets, determined by ORO stain. MEA intake dose-dependently declined reactive oxygen species (ROS) and oxidized glutathione levels, increased glutathione content and maintained the activity of glutathione reductase and catalase in the heart and kidneys of diabetic mice. MEA intake dose-dependently reduced interleukin (IL)-1, IL-6, tumor necrosis factor- and monocyte chemoattractant protein-1 levels in the heart and kidneys of diabetic mice. RA intake at 0.1% declined cardiac and renal levels of these inflammatory factors. These data indicated that MEA improved glycemic control and hemostatic imbalance, lowered lipid accumulation, and attenuated oxidative and inflammatory stress in diabetic mice. Thus, madecassic acid could be considered as an anti-diabetic agent. |
| 资助项目 | Ministry of Science and Technology, Taipei City, Taiwan[NSC 102-2313-B-039 -002 -MY3] ; Ministry of Science and Technology, Taipei City, Taiwan[MOST 103-2313-B-039-002-MY3] |
| WOS关键词 | DIABETES-MELLITUS ; OXIDATIVE STRESS ; CENTELLA-ASIATICA ; HYPERGLYCEMIA ; COAGULATION ; TRITERPENES ; DERIVATIVES ; EXPRESSION ; CYTOKINES ; BARK |
| WOS研究方向 | Nutrition & Dietetics |
| 语种 | 英语 |
| 出版者 | MDPI AG |
| WOS记录号 | WOS:000367052200025 |
| 内容类型 | 期刊论文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276302]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Yin, Mei-chin |
| 作者单位 | 1.Chung Shan Med Univ Hosp, Dept Pathol, Taichung 40402, Taiwan; 2.China Med Univ, Dept Nutr, Taichung 40402, Taiwan 3.China Med Univ, Dept Biol Sci & Technol, Taichung 40402, Taiwan; 4.China Med Univ, Grad Inst Clin Med Sci, Taichung 40402, Taiwan; 5.China Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung 40402, Taiwan; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 7.Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 40402, Taiwan; |
| 推荐引用方式 GB/T 7714 | Hsu, Yuan-Man,Hung, Yi-chih,Hu, Lihong,et al. Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid[J]. NUTRIENTS,2015,7(12):10065-10075. |
| APA | Hsu, Yuan-Man,Hung, Yi-chih,Hu, Lihong,Lee, Yi-ju,&Yin, Mei-chin.(2015).Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid.NUTRIENTS,7(12),10065-10075. |
| MLA | Hsu, Yuan-Man,et al."Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid".NUTRIENTS 7.12(2015):10065-10075. |
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