Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats

doi:10.1016/j.lfs.2015.06.010

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	Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats
	Teng, Fukang 3,4; Yin, Ying 4; Cui, Yajun 1; Deng, Yanping 4; Li, Defang 2; Cho, Kenka 5; Zhang, Ge 2; Lu, Aiping 2; Wu, Wanying4 ; Yang, Min 4
刊名	LIFE SCIENCES
	2016
卷号	144 页码:86-93
关键词	Salvianolic acid A Hypertension Microvascular remodeling Spontaneously hypertensive rats Vascular endothelial function
ISSN号	0024-3205
DOI	10.1016/j.lfs.2015.06.010
文献子类	Article
英文摘要	Aims: Despite the numerous pharmacological agents available for hypertension therapy, hypertension-related microvascular remodeling is not resolved, eventually leading to end-organ damage. The aim of the present study was to investigate the protection of salvianolic acid A (SalA) against microvascular remodeling in vitro and in vivo. Main methods: Spontaneously hypertensive rats (SHRs) were administered 2.5, 5 or 10 mg/kg SalA via intraperitoneal injection once a day for 4 weeks. The tail-cuff method was applied to monitor blood pressure; the microvascular structure of the retina was detected by hematoxylin-eosin and immunohistochemical staining; the function of mesenteric arteries was measured by DMT wire myography; endothelial cell proliferation was estimated using the Cell Counting Kit-8; endothelial cell migration was evaluated by wound healing and transwell assay; and endothelial cell integrity was detected by transendothelial electrical resistance and permeability assays. Key findings: Although no antihypertensive effects of SalA were observed, SalA attenuated the microvascular inward remodeling of the retina and improved microvascular function in the mesenteries in vivo. Further cell experiments confirmed the beneficial effects of SalA on the integrity of the endothelial monolayer in vitro. Significance: Salvianolic acid A inhibited endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats. Therefore, salvianolic acid A could be a potential drug therapy to prevent further targeted organ damage induced by vascular remodeling. (C) 2015 Published by Elsevier Inc.
资助项目	National Natural Science Foundation of China[81173587] ; National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2013ZX09103002-024] ; Shanghai Science and Technology Development Foundation[14401900900] ; Croucher Foundation[CAS14201]
WOS关键词	CHRONIC KIDNEY-DISEASE ; TARGET-ORGAN DAMAGE ; OXIDATIVE STRESS ; RETINOPATHY ; ASSOCIATION ; MICE
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000367234400012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276276]
专题	上海中药现代化研究中心
通讯作者	Yin, Jun
作者单位	1.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong, Hong Kong, Peoples R China 3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo 6660162, Japan;
推荐引用方式 GB/T 7714	Teng, Fukang,Yin, Ying,Cui, Yajun,et al. Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats[J]. LIFE SCIENCES,2016,144:86-93.
APA	Teng, Fukang.,Yin, Ying.,Cui, Yajun.,Deng, Yanping.,Li, Defang.,...&Jiang, Baohong.(2016).Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats.LIFE SCIENCES,144,86-93.
MLA	Teng, Fukang,et al."Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats".LIFE SCIENCES 144(2016):86-93.