A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system

doi:10.1016/j.tetlet.2017.04.073

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	A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system
	Zhou, Yang 3; Chen, Ping 3; Lv, Xue 1; Niu, Junxing 1; Wang, Yingying 1; Lei, Min1 ; Hu, Lihong 1,2
刊名	TETRAHEDRON LETTERS
	2017-06-07
卷号	58 期号:23 页码:2232-2235
关键词	2-Formylbenzoic acid Isoindolin-1-one Pd(OAc)(2) Hydrogenation Cyclization
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2017.04.073
文献子类	Article
英文摘要	A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives from 2-formylbenzoic acid and amine under Pd(OAc)(2)/HCOOH system has been described. The whole process is carried out in ligand-free conditions and furnished the desired products by reductive intramolecular cyclization. Furthermore, this procedure is applied successfully for the modification of natural products, such as vindoline and estrone. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China, China[81473110] ; Special Fund for Strategic Pilot Technology Chinese Academy of Sciences[XDA12040303] ; Shanghai Science & Technology Support Program[13431900401]
WOS关键词	TNF-ALPHA PRODUCTION ; TRANSFER HYDROGENATION ; REDUCTIVE AMINATION ; FORMIC-ACID ; WATER ; CATALYST ; AMINES ; INHIBITORS ; ALKALOIDS ; SOLVENT
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000402355400014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272616]
专题	上海中药现代化研究中心
通讯作者	Lei, Min; Hu, Lihong
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Mat Medica, Chinese Acad Sci, Shanghai, Peoples R China; 2.Nanjing Univ Chinese Med, Jiangsu Key Lab Funct Substance Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Stake Key Lab Cultivat Base TCM Qual & Efficacy,S, Nanjing, Jiangsu, Peoples R China 3.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Yang,Chen, Ping,Lv, Xue,et al. A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system[J]. TETRAHEDRON LETTERS,2017,58(23):2232-2235.
APA	Zhou, Yang.,Chen, Ping.,Lv, Xue.,Niu, Junxing.,Wang, Yingying.,...&Hu, Lihong.(2017).A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system.TETRAHEDRON LETTERS,58(23),2232-2235.
MLA	Zhou, Yang,et al."A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system".TETRAHEDRON LETTERS 58.23(2017):2232-2235.