New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells

doi:10.1016/j.fitote.2017.06.018

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	New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells
	Zhang, Jianqing 1,2; Jin, Qinghao 2; Deng, Yanping 2; Hou, Jinjun2 ; Wu, Wanying2 ; Guo, Dean1,2
刊名	FITOTERAPIA
	2017-09
卷号	121 页码:46-52
关键词	Salvia miltiorrhiza Depsides Radical-scavenging Protective effect H9c2 cells
ISSN号	0367-326X
DOI	10.1016/j.fitote.2017.06.018
文献子类	Article
英文摘要	Phytochemical investigation of the roots of Salvia miltiorrhiza led to isolations of two new depsides (1-2), along with thirteen known compounds (3-15). Their structures and relative stereochemistry were elucidated by NMR spectral (H-1 and C-13 NMR, HSQC, HMBC), CD and HR-ESIMS data analyses. The absolute configuration of 1 was determined by comparison of the experimental and calculated ECD spectra. All the depsides (1 10) were found to exhibit stronger free radical scavenging capacity (ranging from 2.62 to 22.05 mu M) than diterpenoids (11-15, IC50 > 100 mu M), among which Salvianolic acid A and Salvianolic acid B were the most potent compounds. Additionally, most of depsides (1, 3, 5, 7, 8, 9, 10) possessed significant protective effects against H2O2-induced H9c2 apoptosis in low concentrations. The negative mode collision-induced dissociations of compound 1 and 2 were featured by the alpha-cleavage and beta-cleavage to lose danshensu (198 Da) and caffeic acid (180 Da), respectively, while a,13-dihydroxybenzenes depsides (8-hydroxy) showed characteristic neutral elimination of H20.
资助项目	National Natural Science Foundation of China[81530095] ; Shanghai Municipal Science and Technology Commission[15DZ0502800] ; National Standardization Program for Chinese Medicine[ZYBZH-C-SH-49]
WOS关键词	DIODE-ARRAY DETECTION ; ACID-B ; LIQUID-CHROMATOGRAPHY ; DITERPENOID CONSTITUENTS ; MASS-SPECTROMETRY ; DANSHEN ; IDENTIFICATION ; CHEMISTRY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000411543900006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272501]
专题	上海中药现代化研究中心
通讯作者	Wu, Wanying; Guo, Dean
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jianqing,Jin, Qinghao,Deng, Yanping,et al. New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells[J]. FITOTERAPIA,2017,121:46-52.
APA	Zhang, Jianqing,Jin, Qinghao,Deng, Yanping,Hou, Jinjun,Wu, Wanying,&Guo, Dean.(2017).New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells.FITOTERAPIA,121,46-52.
MLA	Zhang, Jianqing,et al."New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells".FITOTERAPIA 121(2017):46-52.