Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

doi:10.1021/acs.nanolett.7b05263

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	Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy
	Zhang, Yu 1; Gai, Kaimin 2; Li, Chao 1; Guo, Qin 1; Chen, Qinjun 1; He, Xi 1; Liu, Lisha 1; Zhang, Yujie 1; Lu, Yifei 1; Chen, Xinli 1
刊名	NANO LETTERS
	2018-03
卷号	18 期号:3 页码:1908-1915
关键词	tumor microenvironment macrophage-membrane coating cascade-responsiveness biomimetic delivery system breast-cancer targeting
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.7b05263
文献子类	Article
英文摘要	Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed to further improve the in situ penetration efficiency of chemo-drug-loaded membrane delivery-system formulations and their release profiles at the tumor site. Here, a macrophage membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli. Upon fulfilling its mission of tumor homing and RES evasion, the macrophage-membrane coating can be shed via morphological changes driven by extracellular microenvironment stimuli. The nanoparticles discharged from the outer membrane coating show penetration efficiency enhanced by their size advantage and surface modifications. After internalization by the tumor cells, the loaded drug is quickly released from the nanoparticles in response to the endosome pH. The designed macrophage-membrane-coated nanoparticle (cskc-PPiP/PTX@Ma) exhibits an enhanced therapeutic effect inherited from both membrane-derived tumor homing and step-by-step controlled drug release. Thus, the combination of a biomimetic cell membrane and a cascade-responsive polymeric nanoparticle embodies an effective drug delivery system tailored to the tumor microenvironment.
资助项目	National Science Fund for Distinguished Young Scholars[81425023] ; National Natural Science Foundation of China[81373355] ; Fudan-SIMM Joint Research Fund[FU-SIMM 20174009] ; NSF[DMR-1309525] ; NIH[R01 1R01CA207584] ; NIH[R21 CA198684] ; Beckman Institute Graduate Fellowship at the University of Illinois at Urbana-Champaign[00000000]
WOS关键词	GENE DELIVERY ; GOLD NANOPARTICLES ; PEPTIDE CHIMERAS ; DRUG-DELIVERY ; CANCER ; THERAPY ; MICROENVIRONMENT ; ENVIRONMENT ; PACLITAXEL ; LIBRARY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000427910600049
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279868]
专题	药物制剂研究中心
通讯作者	Cheng, Jianjun; Jiang, Chen
作者单位	1.Fudan Univ, Key Lab Smart Drug Delivery, State Key Lab Med Neurobiol, Minist Educ,Dept Pharmaceut,Sch Pharm, Shanghai 201203, Peoples R China; 2.Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yu,Gai, Kaimin,Li, Chao,et al. Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy[J]. NANO LETTERS,2018,18(3):1908-1915.
APA	Zhang, Yu.,Gai, Kaimin.,Li, Chao.,Guo, Qin.,Chen, Qinjun.,...&Jiang, Chen.(2018).Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy.NANO LETTERS,18(3),1908-1915.
MLA	Zhang, Yu,et al."Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy".NANO LETTERS 18.3(2018):1908-1915.