Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles

doi:10.1021/nn2033105

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles
	Gao, Yu 1; Chen, Yu 2; Ji, Xiufeng 1; He, Xinyu 1; Yin, Qi1 ; Zhang, Zhiwen1 ; Shi, Jianlin 2; Li, Yaping1
刊名	ACS NANO
	2011-12
卷号	5 期号:12 页码:9788-9798
关键词	multidrug resistance hollow mesoporous silica nanoparticles pore size drug delivery doxorubicin
ISSN号	1936-0851
DOI	10.1021/nn2033105
文献子类	Article
英文摘要	In this work, hollow mesoporous silica nanoparticles (HMSNs) with three pore sizes were manufactured to control the drug release rate, and the biological roles of these HMSNs were evaluated in multidrug-resistant (MDR) cancer cells. As novel pore-size-controllable inorganic materials, HMSNs showed negligible cytotoxicity and efficient cellular uptake toward drug-sensitive MCF-7 and drug-resistant MCF-7/ADR cells. Doxorubicin (DOX)-loaded HMSNs (DMSNs) not only demonstrated effective drug loading and a pH-responsive drug release character but also exhibited pore-size-dependent and sustained drug release performance in both in vitro and intracellular drug release experiments. In addition, DMSNs exhibited pore-size-dependent anticancer activity against MCF-7/ADR cells. DMSNs with larger pore size could mediate more cellular uptake of DOX and faster intracellular drug release, which led to more intracellular drug accumulation and stronger MDR-reversal effects. The MDR-overcoming mechanism could be due to the efficient cellular uptake, P-gp inhibition, and ATP depletion. These results demonstrate that HMSNs could be a very promising drug delivery system for pore-size-controllable drug release and cancer MDR reversion.
资助项目	National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2009CB930304] ; National Basic Research Program of China[2012CB932500] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[50823007] ; Science and Technology Commission of Shanghai[10430712800] ; Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201001]
WOS关键词	ANTICANCER DRUGS ; DELIVERY-SYSTEMS ; THERAPY ; NANOCAPSULES ; CHEMOTHERAPY ; EFFICACY ; CARRIERS ; SIRNA
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000298316700051
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278308]
专题	药物制剂研究中心上海中药现代化研究中心
通讯作者	Shi, Jianlin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;
推荐引用方式 GB/T 7714	Gao, Yu,Chen, Yu,Ji, Xiufeng,et al. Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles[J]. ACS NANO,2011,5(12):9788-9798.
APA	Gao, Yu.,Chen, Yu.,Ji, Xiufeng.,He, Xinyu.,Yin, Qi.,...&Li, Yaping.(2011).Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles.ACS NANO,5(12),9788-9798.
MLA	Gao, Yu,et al."Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles".ACS NANO 5.12(2011):9788-9798.