Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging

doi:10.1039/c2jm35308c

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging
	Niu, Dechao 3; Zhang, Zhiwen4 ; Jiang, Shijun 4; Ma, Zhi 1; Liu, Xiaohang 5; Li, Yongsheng 3; Zhou, Liangping 5; Liu, Changsheng 3; Li, Yaping4 ; Shi, Jianlin 2,3
刊名	JOURNAL OF MATERIALS CHEMISTRY
	2012
卷号	22 期号:47 页码:24936-24944
ISSN号	0959-9428
DOI	10.1039/c2jm35308c
文献子类	Article
英文摘要	In this paper, we report the fabrication, characterization and ex vivo bio-distribution of Rhodamine B-labeled shell cross-linked magnetic micelles (RhB-SCL-MMs) as a T-2-weighted magnetic resonance contrast agent. Three sizes of hybrid micelles (80, 130 and 180 nm) are synthesized and the size effects on the cytotoxicity and cell uptake in macrophage cells (RAW264.7) are evaluated. The ex vivo bio-distribution experiments confirm that the three sizes of RhB-SCL-MMs are mainly accumulated in the liver and spleen after intravenous injection, which suggests that the micelles could be used as an efficient MR contrast agent for liver imaging. In addition, no tissue toxicity is detected in tissue slice tests. The application of RhB-SCL-MMs of different sizes is demonstrated for magnetic resonance imaging (MRI) both in vitro and in vivo. A maximum r(2) value of 320.7 mM(-1) s(-1) is obtained for the RhB-SCL-MMs with the highest loading amount of magnetite, which is much higher than that of the well-known, liver-specific, T-2-weighted contrast agent Feridex (iron oxide, r(2) = 108 mM(-1) s(-1)). The in vivo MRI studies show that the contrast enhancement of RhB-SCL-MMs in the liver is dependent on the diameter of the micelles, where the 130 nm RhB-SCL-MMs exhibit the most significant enhancement. In addition, the multifunctional nanoparticles present promising application potential in liver tumor MR imaging through enhanced permeability and retention (EPR) effect. Therefore, these kinds of iron oxide-based cross-linked micelles could be used as excellent, safe MR contrast agents for the diagnosis of liver diseases or cancers.
资助项目	National Basic Research Program of China (973 Program)[2012CB933602] ; Program for New Century Excellent Talents in University[NCET-10-0379] ; Scientific Innovation Project of Shanghai Municipal Education Commission[11ZZ53] ; National Natural Science Foundation of China[51172070] ; National Natural Science Foundation of China[51132009] ; National Natural Science Foundation of China[51202068] ; Fundamental Research Funds for the Central Universities[WD1114002] ; Fundamental Research Funds for the Central Universities[WD1114010]
WOS关键词	SUPERPARAMAGNETIC IRON-OXIDE ; CONTRAST AGENTS ; ORGANOSILICA NANOPARTICLES ; BLOCK-COPOLYMERS ; CELLS ; NANOCRYSTALS ; PARTICLES ; UNIFORM ; DISEASE ; LINKING
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000311808200059
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278231]
专题	药物制剂研究中心
通讯作者	Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 5.Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China;
推荐引用方式 GB/T 7714	Niu, Dechao,Zhang, Zhiwen,Jiang, Shijun,et al. Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(47):24936-24944.
APA	Niu, Dechao.,Zhang, Zhiwen.,Jiang, Shijun.,Ma, Zhi.,Liu, Xiaohang.,...&Shi, Jianlin.(2012).Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging.JOURNAL OF MATERIALS CHEMISTRY,22(47),24936-24944.
MLA	Niu, Dechao,et al."Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging".JOURNAL OF MATERIALS CHEMISTRY 22.47(2012):24936-24944.