Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier

doi:10.1002/smll.201400775

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	Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier
	Rao, Yue-feng 3,4; Chen, Wei 2; Liang, Xing-guang 4; Huang, Yong-zhuo1 ; Miao, Jing 4; Liu, Lin 4; Lou, Yan 4; Zhang, Xing-guo 4; Wang, Ben 2; Tang, Rui-kang 2
刊名	SMALL
	2015-01-14
卷号	11 期号:2 页码:239-247
关键词	superparamagnetic materials iron oxide nanoparticles drug delivery epirubicin cancer biomedical applications
ISSN号	1613-6810
DOI	10.1002/smll.201400775
文献子类	Article
英文摘要	The transdermal administration of chemotherapeutic agents is a persistent challenge for tumor treatments. A model anticancer agent, epirubicin (EPI), is attached to functionalized superparamagnetic iron-oxide nanoparticles (SPION). The covalent modification of the SPION results in EPI-SPION, a potential drug delivery vector that uses magnetism for the targeted transdermal chemotherapy of skin tumors. The spherical EPI-SPION composite exhibits excellent magnetic responsiveness with a saturation magnetization intensity of 77.8 emu g(-1). They feature specific pH-sensitive drug release, targeting the acidic microenvironment typical in common tumor tissues or endosomes/lysosomes. Cellular uptake studies using human keratinocyte HaCaT cells and melanoma WM266 cells demonstrate that SPION have good biocompatibility. After conjugation with EPI, the nanoparticles can inhibit WM266 cell proliferation; its inhibitory effect on tumor proliferation is determined to be dose-dependent. In vitro transdermal studies demonstrate that the EPI-SPION composites can penetrate deep inside the skin driven by an external magnetic field. The magnetic-field-assisted SPION transdermal vector can circumvent the stratum corneum via follicular pathways. The study indicates the potential of a SPION-based vector for feasible transdermal therapy of skin cancer.
资助项目	National Natural Science Foundation of China[81072231] ; Zhejiang Provincial Natural Science Youth Foundation of China[LQ13H020001]
WOS关键词	DRUG-DELIVERY ; IN-VIVO ; MULTIDRUG-RESISTANCE ; FULL-THICKNESS ; BREAST-CANCER ; SOLID TUMORS ; PENETRATION ; DOXORUBICIN ; PH ; ROUTE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000347784000011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276674]
专题	药物制剂研究中心
通讯作者	Lu, Xiao-yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Dept Chem, Ctr Biomat & Biopathways, Hangzhou 310027, Zhejiang, Peoples R China; 3.Zhejiang Univ, Dept Pharmacol, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 4.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China;
推荐引用方式 GB/T 7714	Rao, Yue-feng,Chen, Wei,Liang, Xing-guang,et al. Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier[J]. SMALL,2015,11(2):239-247.
APA	Rao, Yue-feng.,Chen, Wei.,Liang, Xing-guang.,Huang, Yong-zhuo.,Miao, Jing.,...&Lu, Xiao-yang.(2015).Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier.SMALL,11(2),239-247.
MLA	Rao, Yue-feng,et al."Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier".SMALL 11.2(2015):239-247.