Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides

doi:10.1016/j.apsb.2016.04.001

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	Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides
	Lin, Tingting 1,2; Liu, Ergang 1,2; He, Huining 1; Shin, Meong Cheol 3,4,5; Moon, Cheol 6; Yang, Victor C.1,3; Huang, Yongzhuo2
刊名	ACTA PHARMACEUTICA SINICA B
	2016-07
卷号	6 期号:4 页码:352-358
关键词	Intranasal protein delivery Brain targeting Cell-penetrating peptide Low molecular weigh protamine Blood brain barrier
ISSN号	2211-3835
DOI	10.1016/j.apsb.2016.04.001
文献子类	Article
英文摘要	Brain delivery of macromolecular therapeutics (e.g., proteins) remains an unsolved problem because of the formidable blood brain bather (BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs, new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. h order to overcome the bathers and take advantage of available pathways (e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine (LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides (CPP) have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP proteinsare able to effectively penetrate into the brain after intranasal administration. The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
资助项目	National Basic Research Program of China (973 Program)[2013CB932503] ; National Basic Research Program of China (973 Program)[2014CB931900] ; National Natural Science Foundation of China[81172996] ; National Natural Science Foundation of China[81373357] ; National Natural Science Foundation of China[81422048] ; National Natural Science Foundation of China[81361140344]
WOS关键词	MOLECULAR-WEIGHT PROTAMINE ; IN-VIVO EVALUATION ; PROTEIN TRANSDUCTION ; ASPARAGINASE THERAPY ; HEPARIN ANTAGONIST ; DRUG-DELIVERY ; VITRO ; SYSTEM ; ABSORPTION ; EFFICIENT
WOS研究方向	Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5751696
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000384896100012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275964]
专题	药物制剂研究中心
通讯作者	Yang, Victor C.; Huang, Yongzhuo
作者单位	1.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Michigan, Coll Pharm, 428 Church St, Ann Arbor, MI 48109 USA; 4.Gyeongsang Natl Univ, Coll Pharm, Jinju 660701, Gyeongnam, South Korea; 5.Gyeongsang Natl Univ, Pharmaceut Sci Res Inst, Jinju 660701, Gyeongnam, South Korea; 6.Sunchon Natl Univ, Coll Pharm, Sunchon 540950, Jeonnam, South Korea
推荐引用方式 GB/T 7714	Lin, Tingting,Liu, Ergang,He, Huining,et al. Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides[J]. ACTA PHARMACEUTICA SINICA B,2016,6(4):352-358.
APA	Lin, Tingting.,Liu, Ergang.,He, Huining.,Shin, Meong Cheol.,Moon, Cheol.,...&Huang, Yongzhuo.(2016).Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides.ACTA PHARMACEUTICA SINICA B,6(4),352-358.
MLA	Lin, Tingting,et al."Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides".ACTA PHARMACEUTICA SINICA B 6.4(2016):352-358.