Three dimensional structural insight of laser drilled orifices in osmotic pump tablets

doi:10.1016/j.ejps.2016.08.039

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Three dimensional structural insight of laser drilled orifices in osmotic pump tablets
	Wu, Li 2,3; Wang, Lebing 3,4; Wang, Shuxia 6; Xiao, Tiqiao 1; Chen, Min 1; Shao, Qun 5; York, Peter 5; Singh, Vikaramjeet 3; Yin, Xianzhen 3,5; Gu, Jingkai 2
刊名	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2016-10-10
卷号	93 页码:287-294
关键词	Structure Osmotic pump tablet Synchrotron radiation X-ray microcomputed tomography Laser drilling
ISSN号	0928-0987
DOI	10.1016/j.ejps.2016.08.039
文献子类	Article
英文摘要	The orifice drilled in the membrane as a channel for drug delivery is the key functional part of the osmotic pumps for a controlled drug release system. Reported conventional microscopic evaluations of these orifices have been limited to measurement of two-dimensional cross-section diameters. This study was aimed at establishing a novel method to measure quantitatively the three-dimensional architectures of orifices based on synchrotron radiation X-ray microcomputed tomography (SR-mu CT). Quantitative analysis of architectures extracted from captopril osmotic pumps drilled by a range of operating parameters indicated that laser power correlated with the cross section area, volume, surface area and depth of the orifices, while scanning speed of laser beam showed inverse relationships with the above structure characters. The synchrotron radiation based Fourier transform infrared microspectroscopy mapping showed that there was no apparent chemical change in the surrounding area of the orifice compared with the normal membrane region. Thus SR-mu CT was successfully applied to marketed felodipine osmotic pumps for architectural evaluation of the orifices. In conclusion, the first three-dimensional structural insight of orifices in osmotic pump tablets by SR-mu CT and structural reconstruction for the architectures has provided deeper insight into improving the design of advanced osmotic pumps for controlled drug release. (C) 2016 Published by Elsevier B.V.
资助项目	National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81573615] ; National Science and Technology Major Project[2013ZX09402103]
WOS关键词	CONTROLLED-RELEASE KINETICS ; INDENTED CORE TABLET ; ORAL-DRUG DELIVERY ; SYSTEM ; MICROTOMOGRAPHY ; HYDROCHLORIDE ; BEHAVIOR
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000384853200031
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275861]
专题	药物制剂研究中心分子影像中心（筹）
通讯作者	Yin, Xianzhen; Gu, Jingkai; Zhang, Jiwen
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China; 2.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 4.Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang 330004, Peoples R China; 5.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England 6.Qingdao Kangland Biotech Co Ltd, Qingdao 266000, Peoples R China;
推荐引用方式 GB/T 7714	Wu, Li,Wang, Lebing,Wang, Shuxia,et al. Three dimensional structural insight of laser drilled orifices in osmotic pump tablets[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,93:287-294.
APA	Wu, Li.,Wang, Lebing.,Wang, Shuxia.,Xiao, Tiqiao.,Chen, Min.,...&Zhang, Jiwen.(2016).Three dimensional structural insight of laser drilled orifices in osmotic pump tablets.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,93,287-294.
MLA	Wu, Li,et al."Three dimensional structural insight of laser drilled orifices in osmotic pump tablets".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93(2016):287-294.