Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network

doi:10.1080/03639040701657701

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network
	Xie, Huijun 1,3; Gan, Yong1,3 ; Ma, Suwei 1,3; Gan, Li 1; Chen, Qinghua 2
刊名	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
	2008-04
卷号	34 期号:4 页码:363-372
关键词	artificial neural network response surface method time-dependent tablets isosorbide-5-mononitrate
ISSN号	0363-9045
DOI	10.1080/03639040701657701
文献子类	Article
英文摘要	The aim of this work was to optimize time-dependent tablets using artificial neural network (ANN). The time-dependent tablet consisted of a tablet core, which contained sustained release pellets (70% isosorbide-5-mononitrate [5-ISMN]), immediate release granules (30% 5-ISMN), superdisintegrating agent (sodium carboxymethylstarch, CMS-Na), and other excipients, surrounded by a coating layer composed of a water-insoluble ethylcellulose and a water-soluble channeling agent. The chosen independent variables, i.e., X, coating level of tablets, X-1 coating level of pellets, and X-3 CMS-Na level, were optimized with a three-factor, threelevel Box-Behnken design. Data were analyzed for modeling and optimizing the release profile using ANN. Response surface plots were used to relate the dependent and the independent variables. The optimized values for the factors X-1-X-3 were 4.1, 14.1, and 29.8%, respectively. Optimized formulations were prepared according to the factor combinations dictated by ANN. In each case, the observed drug release data of the optimized formulations were close to the predicted release pattern. An in vitro model for predicting the effect of food on release behavior of optimized products was used in this study. It was concluded that neural network technique could be particularly suitable in the pharmaceutical technology of time-dependent dosage forms where systems were complex and nonlinear relationships often existed between the independent and the dependent variables.
WOS关键词	DISSOLUTION ; FORMULATIONS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000255341600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272947]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	1.Chinese Acad Sci, Inst Mat Medica, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Shanghai Inst Pharmaceut Ind, Shanghai, Peoples R China 3.Shanghai Pharmaceut Grp Co Ltd, Cent Res Inst, Shanghai, Peoples R China;
推荐引用方式 GB/T 7714	Xie, Huijun,Gan, Yong,Ma, Suwei,et al. Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2008,34(4):363-372.
APA	Xie, Huijun,Gan, Yong,Ma, Suwei,Gan, Li,&Chen, Qinghua.(2008).Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,34(4),363-372.
MLA	Xie, Huijun,et al."Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 34.4(2008):363-372.