Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer

doi:10.1016/j.biomaterials.2017.04.028

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	Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer
	Sun, Lijun 1,3; Wang, Dangge 2; Chen, Yu 1; Wang, Liying 1,3; Huang, Ping 1; Li, Yaping2 ; Liu, Ziwei 1; Yao, Heliang 1; Shi, Jianlin 1
刊名	BIOMATERIALS
	2017-07
卷号	133 页码:219-228
关键词	Mesoporous organosilica Multidrug resistance Synergistic therapy Cancer Nanomedicine
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2017.04.028
文献子类	Article
英文摘要	The design and synthesis of hierarchically nanoporous structures for the co-encapsulation and sequential releases of different cargos are still great challenges in biomedical applications. In this work, we report on the elaborate design and controlled synthesis of a unique core-shell hierarchical mesoporous silica/organosilica nanosystem, in which there are large and small mesopores separately present in the shell and core, facilitating the independent encapsulations of large (siRNA) and small (doxorubicin) molecules, respectively. Importantly, the framework of the organosilica shell is molecularly hybridized with disulfide bonds, which enables the unique responsiveness to the reductive tumor microenvironment for the controlled releasing of loaded gene molecules, followed by the subsequent doxorubicin release. The first released large siRNA molecules from the organosilica shell down-regulated the expression of P-gp in the cell membrane and reversed the MDR of cancer cells, thus enhancing the antitumor effect of subsequently released small DOX molecules from the silica core, and in such a synergetic way the MDR tumor growth can be efficiently inhibited. This work shows the significant advantages compared to the traditional small-mesoporous or large-mesoporous nanosystems for drug co-delivery. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	National Key Research and Development Program of China[2016YFA0203700] ; National Nature Science Foundation of China[51302293] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[51672303] ; National Nature Science Foundation of China[81521005] ; Young Elite Scientist Sponsorship Program by CAST[2015QNRC001] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2013169]
WOS关键词	MESOPOROUS ORGANOSILICA NANOPARTICLES ; RESPONSIVE CONTROLLED-RELEASE ; TARGETED DRUG-DELIVERY ; BIOMEDICAL APPLICATIONS ; P-GLYCOPROTEIN ; GENE DELIVERY ; IN-VITRO ; DOXORUBICIN ; SYSTEM ; CHEMOTHERAPY
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000401716700019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272595]
专题	药物制剂研究中心
通讯作者	Chen, Yu; Li, Yaping; Shi, Jianlin
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Sun, Lijun,Wang, Dangge,Chen, Yu,et al. Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer[J]. BIOMATERIALS,2017,133:219-228.
APA	Sun, Lijun.,Wang, Dangge.,Chen, Yu.,Wang, Liying.,Huang, Ping.,...&Shi, Jianlin.(2017).Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer.BIOMATERIALS,133,219-228.
MLA	Sun, Lijun,et al."Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer".BIOMATERIALS 133(2017):219-228.