Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography

doi:10.1016/j.ajps.2017.02.001

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	Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography
	Wu, Li 3; Wang, Manli 2,3; Singh, Vikramjeet 3; Li, Haiyan3 ; Guo, Zhen 1,3; Gui, Shuangying 2; York, Peter 1; Xiao, Tiqiao 4; Yin, Xianzhen 1,3; Zhang, Jiwen2,3
刊名	ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2017-07
卷号	12 期号:4 页码:326-334
关键词	Three dimensional Synchrotron radiation X-ray microcomputed tomography Distribution Microsphere Sucrose stearate
ISSN号	1818-0876
DOI	10.1016/j.ajps.2017.02.001
文献子类	Article
英文摘要	This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography (SR-mu CT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional (3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism. (C) 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.
资助项目	National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2013ZX09402103]
WOS关键词	MICROPARTICLE FORMATION ; SOLVENT EVAPORATION ; PLGA MICROSPHERES ; RELEASE BEHAVIOR ; DRUG-RELEASE ; MECHANISM ; MICROENCAPSULATION ; ENCAPSULATION ; STABILITY ; SINGLE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	HONG KONG ASIAMED PUBLISH HOUSE
WOS记录号	WOS:000412473800002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272574]
专题	药物制剂研究中心
通讯作者	Zhang, Jiwen
作者单位	1.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 2.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230038, Anhui, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wu, Li,Wang, Manli,Singh, Vikramjeet,et al. Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,12(4):326-334.
APA	Wu, Li.,Wang, Manli.,Singh, Vikramjeet.,Li, Haiyan.,Guo, Zhen.,...&Zhang, Jiwen.(2017).Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,12(4),326-334.
MLA	Wu, Li,et al."Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 12.4(2017):326-334.