Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats
	Jiang Shijun 2; Liu Xiujie 2; Huang Jian 1; Gao Fang 1; Gu Wangwen1 ; Cui Jingbin 2
刊名	Chinese Journal of Modern Applied Pharmacy
	2012
卷号	29 期号:1 页码:46-49
关键词	probucol mixed micelle differential scanning calorimetry X-ray diffraction bioavailability
ISSN号	1007-7693
其他题名	普罗布考混合胶束的制备及其大鼠体内药动学研究
文献子类	Article
英文摘要	OBJECTIVE Development of probucol loaded mixed micelles(PMM) for enhancing its oral bioavailability.METHODS PMM was prepared with soybean phosphatidylcholine(EPC) and sodium deoxycholate(SD) by a co-precipitation method.The in vitro properties and in vivo pharmacokinetic behavior of PMM was evaluated.RESULTS The formulation of PMM was optimized as EPC︰SD︰probucol(3︰4︰1).PMM was self-assembled with average diameter of 82.28 nm and polydispersity index of 0.179.Probucol may exhibit as amorphous state in PMM.The in vivo pharmacokinetical results indicated that the peak concentration(Cmax) and area under concentration-time curve(AUC) was significantly improved by 2.28-fold and 4.43-fold,respectively.CONCLUSION The oral bioavailability of probucol was significantly improved by PMM,which could be potential for enhancing the oral absorption of insoluble drugs.
资助项目	国家重点基础研究发展计划[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4444320
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267852]
专题	药物制剂研究中心
作者单位	1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.;
推荐引用方式 GB/T 7714	Jiang Shijun,Liu Xiujie,Huang Jian,et al. Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats[J]. Chinese Journal of Modern Applied Pharmacy,2012,29(1):46-49.
APA	Jiang Shijun,Liu Xiujie,Huang Jian,Gao Fang,Gu Wangwen,&Cui Jingbin.(2012).Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats.Chinese Journal of Modern Applied Pharmacy,29(1),46-49.
MLA	Jiang Shijun,et al."Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats".Chinese Journal of Modern Applied Pharmacy 29.1(2012):46-49.