Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles
	Wang Jing 1; Gan Li 2; Gan Yong2 ; Liu Jianping 1
刊名	Journal of China Pharmaceutical University
	2013
卷号	44 期号:2 页码:117-123
关键词	hyaluronic acid core-shell liponanoparticles dexamethasone sustained release preparation characterization
ISSN号	1000-5048
其他题名	透明质酸修饰的地塞米松核壳纳米粒的制备及表征
文献子类	Article
英文摘要	The aim of this study was to prepare hyaluronic acid-modified dexamethasone-loaded core-shell liponanoparticles and to investigate their physicochemical properties as well as in vitro drug release behavior. Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation, and then the freshly prepared CS-NPs suspension was used to hydrate the dry lipid film to form core-shell liponanoparticles (LCS-NPs). Hyaluronic acid (HA) was conjugated with 1, 2-dioleoyl-sn-glycero-3-phosphor-ethanolamine (DOPE) to form HA-DOPE, which was then incubated with LCS-NPs to get HA-modified LCS-NPs (HA-LCS-NPs). The particle size, Zeta potential, morphology, and composition of HA-LCS-NPs were evaluated. In vitro drug release of HA-LCS-NPs was investigated using dexamethasone as the model drug. Encapsulation efficiency and drug loading capacity of dexamethasoneloaded HA-LCS-NPs were detected via ultracentrifugation. HA-LCS-NPs exhibited clear core-shell structure as can be seen in the TEM images, average size distribution of which was (189 10.3) nm. The encapsulation efficiency and drug loading capacity of dexamethasone-loaded HA-LCS-NPs were 27.4% and 5.9%, respectively. The cumulative release of dexamethasone from HA-LCS-NPs was less than 40% at 72 h. The core-shell liponanoparticles could be successfully prepared by hydrating dry lipid film with suspension of chitosan nanoparticles, followed by modification with HA-DOPE. Dexamethasone could be successfully encapsulated in the HA-LCS-NPs and exhibited sustained release behavior.
资助项目	国家自然科学基金资助项目[00000000] ; 上海市自然科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4816340
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267781]
专题	药物制剂研究中心
作者单位	1.Department of Pharmaceutics,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Wang Jing,Gan Li,Gan Yong,et al. Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles[J]. Journal of China Pharmaceutical University,2013,44(2):117-123.
APA	Wang Jing,Gan Li,Gan Yong,&Liu Jianping.(2013).Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles.Journal of China Pharmaceutical University,44(2),117-123.
MLA	Wang Jing,et al."Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles".Journal of China Pharmaceutical University 44.2(2013):117-123.