Advances in particle shape engineering for improved drug delivery

doi:10.1016/j.drudis.2018.10.006

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Advances in particle shape engineering for improved drug delivery
	Yang, Yiwei 1,3; Nie, Di 1,3; Liu, Yuan 3; Yu, Miaorong 1,3; Gan, Yong2,3
刊名	Drug discovery today
	2018-10-17
ISSN号	1878-5832
DOI	10.1016/j.drudis.2018.10.006
文献子类	Article;Review
英文摘要	Spherical particles such as liposomes and microspheres are the most common and extensively applied drug vehicles. However, researchers have come to realize the superiority of nonspherical nanoparticles. Actually, in human bodies red blood cells, gut biotics and many well-known pathogens have distinct shapes. It can be reasonably inferred that particle shape plays a pivotal part in human bodies. In this review, we summarize the recent studies about the effect of shape on delivery processes such as cellular uptake, tissue penetration and biodistribution. The underlying mechanisms that are relevant to the phenomena revealed, owing to experimental and computational modern techniques, will be addressed, and we shall provide future perspectives on particle design to improve the efficacy of drug delivery.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266327]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	1.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; 2.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai 201203, China;
推荐引用方式 GB/T 7714	Yang, Yiwei,Nie, Di,Liu, Yuan,et al. Advances in particle shape engineering for improved drug delivery[J]. Drug discovery today,2018.
APA	Yang, Yiwei,Nie, Di,Liu, Yuan,Yu, Miaorong,&Gan, Yong.(2018).Advances in particle shape engineering for improved drug delivery.Drug discovery today.
MLA	Yang, Yiwei,et al."Advances in particle shape engineering for improved drug delivery".Drug discovery today (2018).