An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants | |
Cao, Minjie2,3; Liu, Xue2,3,8; Zhang, Yan7; Xue, Xiaoqian6,7; Zhou, X. Edward4; Melcher, Karsten4; Gao, Pan2,3; Wang, Fuxing2,3; Zeng, Liang2,3; Zhao, Yang1,2 | |
刊名 | CELL RESEARCH
![]() |
2013-08 | |
卷号 | 23期号:8页码:1043-1054 |
关键词 | abscisic acid plant hormone drought resistance crystal structure ABA-mimicking ligand |
ISSN号 | 1001-0602 |
DOI | 10.1038/cr.2013.95 |
文献子类 | Article |
英文摘要 | Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphatases (PP2C) and activation of downstream ABA signaling. It is envisioned that intervention of ABA signaling by small molecules could help plants to overcome abiotic stresses such as drought, cold and soil salinity. However, chemical instability and rapid catabolism by plant enzymes limit the practical application of ABA itself. Here we report the identification of a small molecule ABA mimic (AM1) that acts as a potent activator of multiple members of the family of ABA receptors. In Arabidopsis, AM1 activates a gene network that is highly similar to that induced by ABA. Treatments with AM1 inhibit seed germination, prevent leaf water loss, and promote drought resistance. We solved the crystal structure of AM1 in complex with the PYL2 ABA receptor and the HAB1 PP2C, which revealed that AM1 mediates a gate-latch-lock interacting network, a structural feature that is conserved in the ABA-bound receptor/PP2C complex. Together, these results demonstrate that a single small molecule ABA mimic can activate multiple ABA receptors and protect plants from water loss and drought stress. Moreover, the AM1 complex crystal structure provides a structural basis for designing the next generation of ABA-mimicking small molecules. |
资助项目 | Jay and Betty Van Andel Foundation[00000000] ; Amway (China)[00000000] ; National Natural Science Foundation of China[NSFC 91217311] ; US National Institute of Health[R01GM102545] ; Chinese Academy of Sciences[00000000] |
WOS关键词 | ABSCISIC-ACID ; ARABIDOPSIS ; MECHANISM ; PHOSPHATASES ; SOFTWARE ; PROTEINS ; KINASES ; STRESS ; GENE |
WOS研究方向 | Cell Biology |
语种 | 英语 |
CSCD记录号 | CSCD:4907353 |
出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
WOS记录号 | WOS:000322574900011 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/277522] ![]() |
专题 | 药物靶标结构与功能中心 上海药物代谢研究中心 |
通讯作者 | Zhu, Jian-Kang |
作者单位 | 1.Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47906 USA; 2.Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China; 3.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Shanghai 200032, Peoples R China; 4.Van Andel Res Inst, Ctr Struct Biol & Drug Discovery, Lab Struct Sci, Grand Rapids, MI 49503 USA; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; 7.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Struct & Funct Drug Targets, VARI SIMM Ctr,Key Lab Receptor Res, Shanghai 201203, Peoples R China; |
推荐引用方式 GB/T 7714 | Cao, Minjie,Liu, Xue,Zhang, Yan,et al. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants[J]. CELL RESEARCH,2013,23(8):1043-1054. |
APA | Cao, Minjie.,Liu, Xue.,Zhang, Yan.,Xue, Xiaoqian.,Zhou, X. Edward.,...&Xu, Yong.(2013).An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.CELL RESEARCH,23(8),1043-1054. |
MLA | Cao, Minjie,et al."An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants".CELL RESEARCH 23.8(2013):1043-1054. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论