Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang

doi:10.1016/j.jchromb.2006.05.028

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	Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang
	Chen, Ping ; Li, Chuan; Liang, Shipiao ; Song, Guoqiang ; Sun, Yan ; Shi, Yanhong; Xu, Songlin ; Zhang, Jiwen; Sheng, Shuqun ; Yang, Yiming
刊名	JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
	2006-11-07
卷号	843 期号:2 页码:183-193
关键词	LC-hyphenated techniques Xiaochaihu-tang Pinellia ternate
ISSN号	1570-0232
DOI	10.1016/j.jchromb.2006.05.028
文献子类	Article
英文摘要	In traditional Chinese medicine, multiple herbs are usually used in combination to generate the joint actions of a multiherb remedy. The recent development of LC-hyphenated techniques enables efficient and rapid profiling of the chemical constituent in extracts from multiherb remedies. Xiaochaihu-tang is a seven-herb remedy that has attracted a great deal of attention for reported ability to treat liver dysfunction. Dried tubers of Pinellia ternata (banxia in Chinese) is one of the ingredients, but its chemical contribution to Xiaochaihu-tang remains poorly understood. In the study presented here, LC-UV-MS, LC-MS-MS, and LC-NMR were used in a complementary manner to determine the nature and content of eight water-soluble constituents of banxia and their presence in various tea granules from Xiaochaihu-tang. Among the eight chemicals identified in banxia, cytidine, adenosine, tryptophan, uridine, and adenine are reported for the first time, while tyrosine, guanosine, and phenylalanine were previously described. These chemicals are also present in all of the samples of Xiaochaihu-tang granules, and the amounts of the chemicals ingested due to a daily dose of the multiherb remedies range from 0.008 to 6.3 mg, (c) 2006 Elsevier B.V. All rights reserved.
WOS关键词	MAGNETIC-RESONANCE-SPECTROSCOPY ; CHROMATOGRAPHY MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; SHOSAIKO-TO ; LIVER-DISEASE ; DAISAIKO-TO ; HUMAN URINE ; NUTRITIONAL THERAPY ; HERBAL MEDICINES ; IDENTIFICATION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000242361400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273449]
专题	上海药物代谢研究中心
通讯作者	Li, Chuan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Chen, Ping,Li, Chuan,Liang, Shipiao,et al. Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2006,843(2):183-193.
APA	Chen, Ping.,Li, Chuan.,Liang, Shipiao.,Song, Guoqiang.,Sun, Yan.,...&Li, Min.(2006).Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,843(2),183-193.
MLA	Chen, Ping,et al."Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 843.2(2006):183-193.