Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth

doi:10.1016/j.ejmech.2018.01.079

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	Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth
	Zheng, Changping 1; Qu, Huanhuan 4; Liao, Wenfeng 4; Bavaro, Teodora 2; Terreni, Marco 2; Sollogoub, Matthieu 1; Ding, Kan4 ; Zhang, Yongmin 1,3
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2018-02-25
卷号	146 页码:613-620
关键词	Ganglioside GM3 Chemoenzymatic synthesis PC12 cells Neurite outgrowth
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2018.01.079
文献子类	Article
英文摘要	Ganglioside GM3 is implicated in a variety of physiological and pathological processes. Due to GM3 exposes on the outer surface of cell membranes, it is strongly associated with cell adhesion, motility and differentiation. Neurite outgrowth is a key process in the development of functional neuronal circuits and regeneration of the nervous system after injury. In the present study, we used enzymatic hydrolysis and chemical synthesis to obtain novel galactose containing GM3 analogues. By enzymatic hydrolysis to prepare GM3 building block, we can avoid multiple chemical procedures. Next, we employed the PC12 cells as a model to evaluate the effects of GM3 analogues on neurite outgrowth with or without NGF induction, The biological tests showed that GM3 analogues could induce neurite outgrowth, which provides the valuable sights for potential nervous system treatment after injury. (C) 2018 Elsevier Masson SAS. All rights reserved.
资助项目	China Scholarship Council (CSC)[00000000] ; Centre National de la Recherche Scientifique (CNRS)[00000000] ; Sorbonne Universite in France[00000000] ; National Natural Science Foundation of China (NSFC)[21402224] ; Shanghai Science and Technology Development Funds[14YF1407800]
WOS关键词	GROWTH-FACTOR ; GLYCOSPHINGOLIPIDS ; DIFFERENTIATION ; NEURITOGENESIS ; SPHINGOSINES ; SIALYLATION ; CELLS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000427310700049
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279889]
专题	药理学第三研究室
通讯作者	Qu, Huanhuan; Ding, Kan; Zhang, Yongmin
作者单位	1.Sorbonne Univ, CNRS, UMR 8232, IPCM, 4 Pl Jussieu, F-75005 Paris, France; 2.Univ Pavia, Drug Sci Dept, Viale Taramelli 12, I-27100 Pavia, Italy 3.Jianghan Univ, Inst Interdisciplinary Res, Wuhan 430056, Hubei, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zheng, Changping,Qu, Huanhuan,Liao, Wenfeng,et al. Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,146:613-620.
APA	Zheng, Changping.,Qu, Huanhuan.,Liao, Wenfeng.,Bavaro, Teodora.,Terreni, Marco.,...&Zhang, Yongmin.(2018).Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,146,613-620.
MLA	Zheng, Changping,et al."Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 146(2018):613-620.