An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42)

doi:10.1016/j.carbpol.2018.05.022

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42)
	Zhou, Lishuang 2,3; Liao, Wenfeng 2,3; Chen, Xia 2,3; Yue, Han 1,2,3; Li, Saijuan 1,2,3; Ding, Kan1,2,3
刊名	CARBOHYDRATE POLYMERS
	2018-09-01
卷号	195 页码:643-651
关键词	Lycium barbarum Polysaccharide A beta(42) Alzheimer's disease
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.05.022
文献子类	Article
英文摘要	The beta amyloid (A beta) induced neurodegeneration is believed to be one of pathological mechanisms of Alzheimer's disease (AD). The inhibition of A beta production or aggregation is one of the promising therapeutic strategies for anti-AD drug discovery. Here, a homogeneous neutral polysaccharide designated LBP1A1-1 with an average molecular weight of 45.0 kDa was purified from fruits of Lycium barbarum L. Its structure was characterized to possess a backbone of 1, 3-linked beta-Galp, 1,6-linked beta-Galp, 1,4-linked alpha-Glcp with branches substituted at C-3 position of 1,6-linked beta-Galp or C-6 position of 1,3-linked beta-Galp. The branches contained terminal (T)-linked beta-Galp, T-linked alpha-Araf, T-linked beta-Araf, 1,5-linked alpha-Araf and T-linked beta-Rhap. The in vitro experiments revealed that LBP1A1-1 could inhibit A beta(42) production and impede A beta(42) aggregation in a dose-dependent-manner without cytotoxicity. These results suggested that LBP1A1-1 might have the multiple potential for the treatment of AD.
资助项目	Ningxia and Chinese Academy of Sciences, New Drug Creation and Manufacturing Program[2017ZX09305-003] ; National Natural Science Foundation of China[31500651] ; National Natural Science Foundation of China[31230022] ; Ministry of Science and Technology, the People Republic of China, Program of Shanghai Subject Chief Scientist[16XD1404500]
WOS关键词	ANTI-ANGIOGENIC ACTIVITY ; ALZHEIMERS-DISEASE ; AMYLOID-BETA ; POLYSACCHARIDE ; OPTIMIZATION ; HETEROPOLYSACCHARIDE ; NEUROTOXICITY ; RUTHENICUM ; PEPTIDE ; FLOWERS
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000433204900073
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279606]
专题	药理学第三研究室
通讯作者	Liao, Wenfeng; Ding, Kan
作者单位	1.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563000, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Lishuang,Liao, Wenfeng,Chen, Xia,et al. An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42)[J]. CARBOHYDRATE POLYMERS,2018,195:643-651.
APA	Zhou, Lishuang,Liao, Wenfeng,Chen, Xia,Yue, Han,Li, Saijuan,&Ding, Kan.(2018).An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42).CARBOHYDRATE POLYMERS,195,643-651.
MLA	Zhou, Lishuang,et al."An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42)".CARBOHYDRATE POLYMERS 195(2018):643-651.